GFRα3

GFRα3 is a protein that in humans is encoded by the GFRA3 gene. It is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

Function

GFRα3 is a receptor for neurturin (NTN). Together with the GDNF, NTN forms complexes with and mediates the activity of the RET proto-oncogene. GFRα3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

Clinical significance

Alterations in the GFRA3 gene have been associated with Hirschsprung's disease, a genetic disorder that results in an absence of nerve cells in the colon, leading to severe constipation and intestinal obstruction.

See also

• GDNF family receptor alpha
• RET proto-oncogene

References

<references />

External links

• GFRA3 at the National Center for Biotechnology Information

This article is a medical stub. You can help WikiMD by expanding it!
Most recent articles Ongoing trials	Wikipedia