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{{short description|American biopharmaceutical company}}
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[[File:Trevena_logo.svg|Trevena, Inc. logo|thumb|right]]
[[File:Trevena_logo.svg|Trevena, Inc. logo|thumb|right]]


'''Trevena, Inc.''' is an American [[biopharmaceutical company]] focused on the development of novel [[therapeutics]] for the treatment of [[central nervous system]] (CNS) disorders. The company is headquartered in [[Chesterbrook, Pennsylvania]].
'''Trevena, Inc.''' is a [[biopharmaceutical company]] based in the [[United States]] that focuses on the development of novel [[therapeutics]] for the treatment of [[central nervous system]] (CNS) disorders. The company is known for its innovative approach to drug discovery, particularly in the area of [[G protein-coupled receptors]] (GPCRs).


==History==
==History==
Trevena, Inc. was founded in 2007 by a team of scientists from [[Duke University]] and other institutions. The company was established to leverage new insights into [[G protein-coupled receptors]] (GPCRs) to develop innovative therapies. Trevena went public in 2014, listing on the [[NASDAQ]] under the ticker symbol TRVN.
Trevena, Inc. was founded in 2007 by a team of scientists and entrepreneurs with a vision to leverage cutting-edge research in GPCR biology to develop new therapies. The company was initially supported by venture capital funding and has since grown to become a publicly traded entity on the [[NASDAQ]] stock exchange under the ticker symbol TRVN.


==Research and Development==
==Research and Development==
Trevena's research focuses on the development of biased ligands for GPCRs, which are designed to selectively activate specific signaling pathways. This approach aims to improve the therapeutic profile of drugs by enhancing efficacy and reducing side effects.
Trevena's research and development efforts are centered around the modulation of GPCRs, which are a large family of cell surface receptors that play a crucial role in many physiological processes. The company employs a proprietary platform to design biased ligands, which selectively activate specific signaling pathways associated with GPCRs, potentially leading to improved therapeutic outcomes with fewer side effects.


===Oliceridine===
===Key Products===
One of Trevena's lead products is [[oliceridine]], a novel [[opioid]] analgesic designed to provide pain relief with fewer side effects compared to traditional opioids. Oliceridine acts as a biased ligand at the [[mu-opioid receptor]], preferentially activating the G protein pathway over the beta-arrestin pathway, which is associated with many of the adverse effects of opioids.
One of Trevena's most notable products is [[oliceridine]], a novel [[opioid]] analgesic designed to provide effective pain relief with a reduced risk of adverse effects commonly associated with traditional opioids, such as [[respiratory depression]] and [[constipation]]. Oliceridine has been approved by the [[U.S. Food and Drug Administration]] (FDA) for the management of acute pain in adults.


===Other Pipeline Products===
==Pipeline==
Trevena is also developing other CNS-targeted therapies, including TRV734, a follow-up to oliceridine, and TRV250, a treatment for [[migraine]]. These compounds are in various stages of clinical development.
Trevena continues to advance its pipeline of drug candidates targeting various CNS disorders. The company's research is focused on developing treatments for conditions such as [[migraine]], [[depression]], and [[Parkinson's disease]].


==Business Strategy==
==Corporate Structure==
Trevena's business strategy involves advancing its pipeline through clinical trials and seeking strategic partnerships to support the commercialization of its products. The company aims to address unmet medical needs in pain management and other CNS disorders.
Trevena is headquartered in [[Chesterbrook, Pennsylvania]], and operates with a team of experienced professionals in the fields of drug discovery, clinical development, and regulatory affairs. The company collaborates with academic institutions and other biopharmaceutical companies to enhance its research capabilities and accelerate the development of its drug candidates.
 
==Corporate Governance==
Trevena is governed by a board of directors with extensive experience in the pharmaceutical and biotechnology industries. The company's leadership team includes experts in drug development, regulatory affairs, and business operations.


==Related pages==
==Related pages==
* [[Biotechnology]]
* [[Biopharmaceutical]]
* [[Pharmaceutical industry]]
* [[G protein-coupled receptor]]
* [[Drug development]]
* [[Opioid]]
* [[Central nervous system]]
* [[Central nervous system]]


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[[Category:Companies based in Pennsylvania]]
[[Category:Companies based in Pennsylvania]]
[[Category:Companies established in 2007]]
[[Category:Companies established in 2007]]
[[Category:Companies listed on NASDAQ]]
[[Category:Pharmaceutical companies of the United States]]

Latest revision as of 01:35, 7 March 2025


Trevena, Inc. logo

Trevena, Inc. is a biopharmaceutical company based in the United States that focuses on the development of novel therapeutics for the treatment of central nervous system (CNS) disorders. The company is known for its innovative approach to drug discovery, particularly in the area of G protein-coupled receptors (GPCRs).

History[edit]

Trevena, Inc. was founded in 2007 by a team of scientists and entrepreneurs with a vision to leverage cutting-edge research in GPCR biology to develop new therapies. The company was initially supported by venture capital funding and has since grown to become a publicly traded entity on the NASDAQ stock exchange under the ticker symbol TRVN.

Research and Development[edit]

Trevena's research and development efforts are centered around the modulation of GPCRs, which are a large family of cell surface receptors that play a crucial role in many physiological processes. The company employs a proprietary platform to design biased ligands, which selectively activate specific signaling pathways associated with GPCRs, potentially leading to improved therapeutic outcomes with fewer side effects.

Key Products[edit]

One of Trevena's most notable products is oliceridine, a novel opioid analgesic designed to provide effective pain relief with a reduced risk of adverse effects commonly associated with traditional opioids, such as respiratory depression and constipation. Oliceridine has been approved by the U.S. Food and Drug Administration (FDA) for the management of acute pain in adults.

Pipeline[edit]

Trevena continues to advance its pipeline of drug candidates targeting various CNS disorders. The company's research is focused on developing treatments for conditions such as migraine, depression, and Parkinson's disease.

Corporate Structure[edit]

Trevena is headquartered in Chesterbrook, Pennsylvania, and operates with a team of experienced professionals in the fields of drug discovery, clinical development, and regulatory affairs. The company collaborates with academic institutions and other biopharmaceutical companies to enhance its research capabilities and accelerate the development of its drug candidates.

Related pages[edit]