JJC8-088: Difference between revisions
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{{Short description|Chemical compound}} | {{Short description|Chemical compound}} | ||
{{DISPLAYTITLE:JJC8-088}} | |||
[[File:JJC8-088.svg|Chemical structure of JJC8-088|thumb|right]] | |||
'''JJC8-088''' is a chemical compound that acts as a potent and selective antagonist of the [[sigma-1 receptor]]. It is primarily used in scientific research to explore the role of sigma receptors in various physiological and pathological processes. | |||
JJC8-088 is a synthetic compound with a complex | ==Chemical Properties== | ||
JJC8-088 is a synthetic compound with a complex chemical structure. The molecular formula of JJC8-088 is C<sub>22</sub>H<sub>28</sub>FN<sub>3</sub>O<sub>2</sub>, and it has a molecular weight of 385.48 g/mol. The compound is characterized by its high affinity for the sigma-1 receptor, which is a chaperone protein involved in modulating ion channels and other cellular processes. | |||
==Pharmacology== | ==Pharmacology== | ||
JJC8-088 | JJC8-088 is known for its high selectivity towards the sigma-1 receptor, with minimal activity at other receptor sites. This selectivity makes it a valuable tool in research settings, allowing scientists to study the specific effects of sigma-1 receptor modulation without interference from other receptor systems. | ||
===Mechanism of Action=== | |||
The sigma-1 receptor is involved in a variety of cellular functions, including calcium signaling, neuroprotection, and modulation of neurotransmitter systems. JJC8-088 binds to the sigma-1 receptor, inhibiting its activity and thereby affecting these cellular processes. This can lead to changes in neuronal excitability, protection against cellular stress, and modulation of pain perception. | |||
==Research Applications== | ==Research Applications== | ||
JJC8-088 is used extensively in | JJC8-088 is used extensively in preclinical research to investigate the role of sigma-1 receptors in various conditions, such as [[neuropathic pain]], [[depression]], and [[neurodegenerative diseases]]. By blocking the sigma-1 receptor, researchers can study the potential therapeutic effects of sigma-1 receptor antagonism in these conditions. | ||
==Potential Therapeutic Uses== | ===Potential Therapeutic Uses=== | ||
While JJC8-088 is not | While JJC8-088 itself is not used clinically, its ability to modulate sigma-1 receptor activity suggests potential therapeutic applications for sigma-1 receptor antagonists in treating conditions like chronic pain, [[Alzheimer's disease]], and [[schizophrenia]]. | ||
==Safety and Toxicology== | ==Safety and Toxicology== | ||
As with many research chemicals, the safety | As with many research chemicals, the safety profile of JJC8-088 is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented. Researchers handling JJC8-088 must follow appropriate safety protocols to minimize exposure and potential risks. | ||
==Related Pages== | ==Related Pages== | ||
* [[ | * [[Sigma receptor]] | ||
* [[ | * [[Neuropathic pain]] | ||
* [[ | * [[Neuroprotection]] | ||
* [[ | * [[Chaperone protein]] | ||
[[Category: | [[Category:Sigma receptor ligands]] | ||
[[Category:Research chemicals]] | [[Category:Research chemicals]] | ||
[[Category:Experimental drugs]] | |||
Latest revision as of 03:17, 6 March 2025
Chemical compound
JJC8-088 is a chemical compound that acts as a potent and selective antagonist of the sigma-1 receptor. It is primarily used in scientific research to explore the role of sigma receptors in various physiological and pathological processes.
Chemical Properties[edit]
JJC8-088 is a synthetic compound with a complex chemical structure. The molecular formula of JJC8-088 is C22H28FN3O2, and it has a molecular weight of 385.48 g/mol. The compound is characterized by its high affinity for the sigma-1 receptor, which is a chaperone protein involved in modulating ion channels and other cellular processes.
Pharmacology[edit]
JJC8-088 is known for its high selectivity towards the sigma-1 receptor, with minimal activity at other receptor sites. This selectivity makes it a valuable tool in research settings, allowing scientists to study the specific effects of sigma-1 receptor modulation without interference from other receptor systems.
Mechanism of Action[edit]
The sigma-1 receptor is involved in a variety of cellular functions, including calcium signaling, neuroprotection, and modulation of neurotransmitter systems. JJC8-088 binds to the sigma-1 receptor, inhibiting its activity and thereby affecting these cellular processes. This can lead to changes in neuronal excitability, protection against cellular stress, and modulation of pain perception.
Research Applications[edit]
JJC8-088 is used extensively in preclinical research to investigate the role of sigma-1 receptors in various conditions, such as neuropathic pain, depression, and neurodegenerative diseases. By blocking the sigma-1 receptor, researchers can study the potential therapeutic effects of sigma-1 receptor antagonism in these conditions.
Potential Therapeutic Uses[edit]
While JJC8-088 itself is not used clinically, its ability to modulate sigma-1 receptor activity suggests potential therapeutic applications for sigma-1 receptor antagonists in treating conditions like chronic pain, Alzheimer's disease, and schizophrenia.
Safety and Toxicology[edit]
As with many research chemicals, the safety profile of JJC8-088 is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented. Researchers handling JJC8-088 must follow appropriate safety protocols to minimize exposure and potential risks.
