Cridanimod: Difference between revisions
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{{Short description| | {{Short description|Synthetic immunomodulator}} | ||
{{Drugbox | {{Drugbox | ||
| verifiedfields = changed | | verifiedfields = changed | ||
| verifiedrevid = | | verifiedrevid = 477002002 | ||
| IUPAC_name = 2-[[4-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]amino]-2-oxoethyl nitrate | |||
| image = Cridanimod.svg | | image = Cridanimod.svg | ||
| | | image_size = 200px | ||
| image_alt = Chemical structure of Cridanimod | |||
}} | }} | ||
'''Cridanimod''' is a synthetic | '''Cridanimod''' is a synthetic immunomodulator that has been investigated for its potential use in the treatment of certain types of cancer, particularly [[endometrial cancer]]. It is known to enhance the expression of [[progesterone receptor]]s, which can be beneficial in hormone therapy for cancers that are sensitive to hormonal changes. | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Cridanimod functions primarily | Cridanimod functions primarily by modulating the immune response. It is believed to increase the production of [[interferon]]s, which are proteins that play a crucial role in the immune system's ability to combat cancer cells. By enhancing the expression of progesterone receptors, cridanimod may improve the effectiveness of [[progestin]] therapy in hormone receptor-positive cancers. | ||
==Clinical Applications== | ==Clinical Applications== | ||
Cridanimod has been studied in | Cridanimod has been studied in clinical trials for its potential to treat endometrial cancer. In these studies, it is often used in combination with other hormonal therapies to assess its efficacy in enhancing treatment outcomes. The drug's ability to upregulate progesterone receptors makes it a candidate for combination therapy in hormone-sensitive cancers. | ||
==Pharmacokinetics== | ==Pharmacokinetics== | ||
The pharmacokinetic profile of cridanimod involves its absorption, distribution, metabolism, and excretion | The pharmacokinetic profile of cridanimod involves its absorption, distribution, metabolism, and excretion. As a synthetic compound, it is designed to be efficiently absorbed and to exert its effects at the cellular level by interacting with immune cells and hormone receptors. | ||
==Side Effects== | ==Side Effects== | ||
The side effects of cridanimod are similar to those of other immunomodulatory agents. Patients may experience flu-like symptoms, such as fever and fatigue, due to the increased production of interferons. Other potential side effects include nausea, headache, and injection site reactions. | |||
==Research and Development== | ==Research and Development== | ||
Research | Research on cridanimod is ongoing, with studies focusing on its role in combination therapies for cancer treatment. The drug's ability to modulate the immune system and enhance hormone receptor expression makes it a promising candidate for further investigation in oncology. | ||
==Related Pages== | ==Related Pages== | ||
* [[Endometrial cancer]] | * [[Endometrial cancer]] | ||
* [[Progesterone receptor]] | * [[Progesterone receptor]] | ||
* [[ | * [[Immunotherapy]] | ||
* [[ | * [[Hormone therapy (oncology)]] | ||
[[Category: | [[Category:Immunomodulators]] | ||
[[Category:Experimental cancer drugs]] | [[Category:Experimental cancer drugs]] | ||
Latest revision as of 21:08, 5 March 2025
Synthetic immunomodulator
{{Drugbox
| verifiedfields = changed
| verifiedrevid = 477002002
| IUPAC_name = 2-[[4-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]amino]-2-oxoethyl nitrate
| image = Cridanimod.svg
| image_size = 200px
| image_alt = Chemical structure of Cridanimod
}}
Cridanimod is a synthetic immunomodulator that has been investigated for its potential use in the treatment of certain types of cancer, particularly endometrial cancer. It is known to enhance the expression of progesterone receptors, which can be beneficial in hormone therapy for cancers that are sensitive to hormonal changes.
Mechanism of Action[edit]
Cridanimod functions primarily by modulating the immune response. It is believed to increase the production of interferons, which are proteins that play a crucial role in the immune system's ability to combat cancer cells. By enhancing the expression of progesterone receptors, cridanimod may improve the effectiveness of progestin therapy in hormone receptor-positive cancers.
Clinical Applications[edit]
Cridanimod has been studied in clinical trials for its potential to treat endometrial cancer. In these studies, it is often used in combination with other hormonal therapies to assess its efficacy in enhancing treatment outcomes. The drug's ability to upregulate progesterone receptors makes it a candidate for combination therapy in hormone-sensitive cancers.
Pharmacokinetics[edit]
The pharmacokinetic profile of cridanimod involves its absorption, distribution, metabolism, and excretion. As a synthetic compound, it is designed to be efficiently absorbed and to exert its effects at the cellular level by interacting with immune cells and hormone receptors.
Side Effects[edit]
The side effects of cridanimod are similar to those of other immunomodulatory agents. Patients may experience flu-like symptoms, such as fever and fatigue, due to the increased production of interferons. Other potential side effects include nausea, headache, and injection site reactions.
Research and Development[edit]
Research on cridanimod is ongoing, with studies focusing on its role in combination therapies for cancer treatment. The drug's ability to modulate the immune system and enhance hormone receptor expression makes it a promising candidate for further investigation in oncology.
