N-Phenylacetyl-L-prolylglycine ethyl ester: Difference between revisions

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{{DISPLAYTITLE:N-Phenylacetyl-L-prolylglycine ethyl ester}}
{{Short description|A synthetic nootropic compound}}
{{DISPLAYTITLE:''N''-Phenylacetyl-''L''-prolylglycine ethyl ester}}


[[File:Noopept.svg|Chemical structure of N-Phenylacetyl-L-prolylglycine ethyl ester|thumb|right]]
[[File:Noopept.svg|Chemical structure of Noopept|thumb|right]]


'''N-Phenylacetyl-L-prolylglycine ethyl ester''', commonly known as '''Noopept''', is a synthetic [[nootropic]] compound. It is often marketed as a cognitive enhancer, purported to improve memory, learning, and overall cognitive function. Noopept is structurally related to the [[racetam]] family of nootropics, although it is not a racetam itself.
'''''N''-Phenylacetyl-''L''-prolylglycine ethyl ester''''' is a synthetic nootropic compound that is often marketed under the brand name '''Noopept'''. It is a [[peptide]]-derived compound that is structurally related to the [[racetam]] family of nootropics, although it is not a racetam itself. Noopept is known for its potential cognitive-enhancing effects and is used by some individuals to improve memory, focus, and overall cognitive function.


==Chemical Structure and Properties==
==Chemical Structure and Properties==
N-Phenylacetyl-L-prolylglycine ethyl ester is a small peptide molecule. Its chemical structure consists of a phenylacetyl group attached to a prolylglycine moiety, with an ethyl ester functional group. This structure is believed to contribute to its ability to cross the [[blood-brain barrier]] and exert effects on the central nervous system.
Noopept is a dipeptide compound, meaning it is composed of two amino acids linked together. Its chemical structure includes a phenylacetyl group attached to a prolylglycine ethyl ester. The presence of the phenylacetyl group is thought to contribute to its ability to cross the [[blood-brain barrier]], allowing it to exert its effects on the central nervous system.


[[File:Noopept.png|Molecular model of Noopept|thumb|left]]
==Mechanism of Action==
The exact mechanism of action of Noopept is not fully understood, but it is believed to enhance cognitive function through several pathways:


==Mechanism of Action==
* '''Neuroprotection''': Noopept is thought to have neuroprotective properties, potentially reducing oxidative stress and protecting neurons from damage.
The exact mechanism of action of Noopept is not fully understood, but it is thought to involve modulation of [[glutamate]] receptors, particularly the [[AMPA receptor|AMPA]] and [[NMDA receptor|NMDA]] subtypes. Noopept may enhance the expression of [[brain-derived neurotrophic factor]] (BDNF) and [[nerve growth factor]] (NGF), which are proteins involved in the growth and survival of neurons. This action is believed to underlie its potential neuroprotective and cognitive-enhancing effects.
* '''Cholinergic System''': It may modulate the [[cholinergic system]], enhancing the activity of [[acetylcholine]], a neurotransmitter associated with learning and memory.
* '''Glutamatergic System''': Noopept may influence the [[glutamatergic system]], which is involved in synaptic plasticity and cognitive processes.
* '''Brain-Derived Neurotrophic Factor (BDNF)''': Some studies suggest that Noopept may increase the expression of BDNF, a protein that supports the survival and growth of neurons.
 
==Uses and Benefits==
Noopept is primarily used as a cognitive enhancer. Users report benefits such as improved memory, increased focus, and enhanced learning ability. It is also sometimes used to alleviate symptoms of anxiety and depression, although these effects are less well-documented.


==Potential Benefits==
==Dosage and Administration==
Noopept is claimed to offer several cognitive benefits, including:
Noopept is typically administered orally, with common dosages ranging from 10 to 30 mg per day. It is often recommended to start with a lower dose to assess individual tolerance and response. Due to its potency, Noopept is usually taken in cycles, with breaks in between to prevent tolerance buildup.
* Improved memory and learning capacity
* Enhanced focus and attention
* Neuroprotection against oxidative stress and neurotoxicity
* Reduction of anxiety and improvement in mood


==Usage and Dosage==
==Side Effects and Safety==
Noopept is typically administered orally, with recommended dosages ranging from 10 to 30 mg per day. It is often taken in cycles, with breaks in between to prevent tolerance. Users are advised to start with the lowest effective dose and adjust based on individual response.
While Noopept is generally considered safe when used at recommended dosages, some users may experience side effects such as headaches, irritability, or insomnia. It is important to use Noopept responsibly and consult with a healthcare professional if any adverse effects occur.


==Safety and Side Effects==
[[File:Noopept.png|Noopept in powder form|thumb|left]]
Noopept is generally considered to be well-tolerated, with few reported side effects. However, some users may experience headaches, irritability, or gastrointestinal discomfort. Long-term safety data is limited, and individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before use.


==Legal Status==
==Legal Status==
The legal status of Noopept varies by country. In some regions, it is available as a dietary supplement, while in others, it may be classified as a prescription medication or controlled substance. Users should verify the legal status of Noopept in their respective countries before purchasing or using the compound.
The legal status of Noopept varies by country. In some regions, it is available as a dietary supplement, while in others, it may be classified as a prescription medication or a controlled substance. Users should be aware of the regulations in their specific location before purchasing or using Noopept.


==Related Pages==
==Related Pages==
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* [[Racetam]]
* [[Racetam]]
* [[Cognitive enhancement]]
* [[Cognitive enhancement]]
* [[Glutamate receptor]]
* [[Neurotransmitter]]


[[Category:Nootropics]]
[[Category:Nootropics]]
[[Category:Peptides]]
[[Category:Peptides]]

Latest revision as of 06:44, 5 March 2025

A synthetic nootropic compound



Chemical structure of Noopept

N-Phenylacetyl-L-prolylglycine ethyl ester is a synthetic nootropic compound that is often marketed under the brand name Noopept. It is a peptide-derived compound that is structurally related to the racetam family of nootropics, although it is not a racetam itself. Noopept is known for its potential cognitive-enhancing effects and is used by some individuals to improve memory, focus, and overall cognitive function.

Chemical Structure and Properties[edit]

Noopept is a dipeptide compound, meaning it is composed of two amino acids linked together. Its chemical structure includes a phenylacetyl group attached to a prolylglycine ethyl ester. The presence of the phenylacetyl group is thought to contribute to its ability to cross the blood-brain barrier, allowing it to exert its effects on the central nervous system.

Mechanism of Action[edit]

The exact mechanism of action of Noopept is not fully understood, but it is believed to enhance cognitive function through several pathways:

  • Neuroprotection: Noopept is thought to have neuroprotective properties, potentially reducing oxidative stress and protecting neurons from damage.
  • Cholinergic System: It may modulate the cholinergic system, enhancing the activity of acetylcholine, a neurotransmitter associated with learning and memory.
  • Glutamatergic System: Noopept may influence the glutamatergic system, which is involved in synaptic plasticity and cognitive processes.
  • Brain-Derived Neurotrophic Factor (BDNF): Some studies suggest that Noopept may increase the expression of BDNF, a protein that supports the survival and growth of neurons.

Uses and Benefits[edit]

Noopept is primarily used as a cognitive enhancer. Users report benefits such as improved memory, increased focus, and enhanced learning ability. It is also sometimes used to alleviate symptoms of anxiety and depression, although these effects are less well-documented.

Dosage and Administration[edit]

Noopept is typically administered orally, with common dosages ranging from 10 to 30 mg per day. It is often recommended to start with a lower dose to assess individual tolerance and response. Due to its potency, Noopept is usually taken in cycles, with breaks in between to prevent tolerance buildup.

Side Effects and Safety[edit]

While Noopept is generally considered safe when used at recommended dosages, some users may experience side effects such as headaches, irritability, or insomnia. It is important to use Noopept responsibly and consult with a healthcare professional if any adverse effects occur.

Noopept in powder form

Legal Status[edit]

The legal status of Noopept varies by country. In some regions, it is available as a dietary supplement, while in others, it may be classified as a prescription medication or a controlled substance. Users should be aware of the regulations in their specific location before purchasing or using Noopept.

Related Pages[edit]