KCNE2

KCNE2 is a gene that in humans encodes the potassium voltage-gated channel subfamily E regulatory beta subunit 2. This gene is a member of the KCNE family of genes, which are known to modulate the function of potassium channels.

Function

The KCNE2 gene encodes a member of the KCNE family of proteins, which are small proteins that associate with the voltage-gated potassium (Kv) channels and modulate their function. The protein encoded by this gene is known to associate with the KCNQ1 gene product, a protein involved in repolarizing the cardiac action potential, and in the IKs current, which contributes to the cardiac action potential.

Clinical significance

Mutations in the KCNE2 gene have been associated with Long QT syndrome, a disorder of the heart's electrical activity that can cause sudden, uncontrollable, and irregular heartbeats (arrhythmias), which may lead to sudden death. It has also been associated with Atrial fibrillation, a common type of abnormal heart rhythm.

See also

• Voltage-gated potassium channel
• KCNQ1
• Long QT syndrome
• Atrial fibrillation

References

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External links

• KCNE2 at the NCBI Gene

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KCNE2

• File:Differential-Association-between-HERG-and-KCNE1-or-KCNE2-pone.0000933.s002.ogv

KCNE2

• Differential Association between HERG and KCNE1 or KCNE2
  Differential Association between HERG and KCNE1 or KCNE2