Reactive lymphocyte: Difference between revisions
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== Morphology == | == Morphology == | ||
Reactive lymphocytes are characterized by their increased size, often measuring 12-30 micrometers in diameter. They have abundant cytoplasm, which can appear basophilic and may contain vacuoles. The nucleus of a reactive lymphocyte is often irregularly shaped, with a coarse chromatin pattern. The nucleoli may be prominent, and the nuclear membrane can be indented or folded. | Reactive lymphocytes are characterized by their increased size, often measuring 12-30 micrometers in diameter. They have abundant cytoplasm, which can appear basophilic and may contain vacuoles. The nucleus of a reactive lymphocyte is often irregularly shaped, with a coarse chromatin pattern. The nucleoli may be prominent, and the nuclear membrane can be indented or folded. | ||
Latest revision as of 23:02, 21 February 2025
Reactive Lymphocyte[edit]
A reactive lymphocyte is a type of lymphocyte that has been activated in response to an antigen. These cells are typically larger than normal lymphocytes and exhibit a variety of morphological changes. Reactive lymphocytes are often seen in the context of viral infections, such as infectious mononucleosis, and other immune responses.
Morphology[edit]
Reactive lymphocytes are characterized by their increased size, often measuring 12-30 micrometers in diameter. They have abundant cytoplasm, which can appear basophilic and may contain vacuoles. The nucleus of a reactive lymphocyte is often irregularly shaped, with a coarse chromatin pattern. The nucleoli may be prominent, and the nuclear membrane can be indented or folded.
Causes[edit]
Reactive lymphocytes are typically seen in response to:
- Viral infections such as Epstein-Barr virus (EBV), cytomegalovirus (CMV), and HIV.
- Bacterial infections like tuberculosis and brucellosis.
- Autoimmune disorders such as systemic lupus erythematosus (SLE).
- Drug reactions and allergic reactions.
Clinical Significance[edit]
The presence of reactive lymphocytes in a blood smear can be an important diagnostic clue. In the context of infectious mononucleosis, for example, the presence of atypical lymphocytes is a hallmark finding. Reactive lymphocytes can also be seen in other conditions, and their presence should be interpreted in conjunction with clinical findings and other laboratory tests.
