Cyclopentobarbital

Cyclopentobarbital, also known as cyclobarbital or cyclobarbitone, is a drug that belongs to the barbiturate class. It was widely used in the mid-20th century for a range of purposes, including as a sleeping pill, sedative, and anticonvulsant. However, its use has declined due to the development of safer alternatives.

History

Cyclopentobarbital was first synthesized in the early 20th century. It was one of the first barbiturates to be used in medicine, and it quickly gained popularity due to its potent sedative effects. However, it also had a high potential for addiction and overdose, which led to its eventual decline in use.

Pharmacology

Cyclopentobarbital works by increasing the activity of GABA, a neurotransmitter that inhibits brain activity. This results in a decrease in nerve cell activity, leading to sedation and sleep. However, high doses can cause respiratory depression, coma, and death.

Medical uses

Cyclopentobarbital was used for a variety of medical purposes, including as a treatment for insomnia, anxiety, and certain types of seizures. It was also used to induce sleep before surgery.

Side effects

Common side effects of cyclopentobarbital include drowsiness, dizziness, and impaired coordination. More serious side effects can include respiratory depression, addiction, and overdose.

See also

• Barbiturate
• Drug addiction
• Overdose

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