Ditolylguanidine

Ditolylguanidine (also known as DTG) is a selective sigma receptor agonist, with a reported preference for the sigma-1 subtype. It has been used in scientific research to explore the function of sigma receptors, and has been found to produce convulsions in animals, suggesting a possible role for sigma receptors in the regulation of seizure activity.

Pharmacology

DTG is a selective sigma receptor agonist, with a reported preference for the sigma-1 subtype. Sigma receptors were originally thought to be a type of opioid receptor, due to the ability of many sigma agonists to produce convulsions, but this has since been disproven and sigma receptors are now considered to be a distinct class of proteins. DTG has been found to produce convulsions in animals, suggesting a possible role for sigma receptors in the regulation of seizure activity.

Research

DTG has been used in scientific research to explore the function of sigma receptors. It has been found to produce convulsions in animals, suggesting a possible role for sigma receptors in the regulation of seizure activity. Other studies have looked at the potential role of sigma receptors in the regulation of mood and the effects of antipsychotic drugs.

See also

• Sigma receptor
• Sigma-1 receptor
• Sigma-2 receptor
• Opioid receptor
• Antipsychotic

References

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Ditolylguanidine

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  1,3-Ditolylguanidine structure
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  Ditolylguanidine 3D model