TAS2R10

TAS2R10 is a protein that in humans is encoded by the TAS2R10 gene. It is a member of the bitter taste receptor family, which is a group of G protein-coupled receptors. This family is specifically known for their role in the detection of bitter compounds, and are thus thought to protect the body from potentially harmful substances.

Function

TAS2R10 is a taste receptor that functions in the perception of bitter taste. It is found in the taste buds on the tongue and in the gastrointestinal tract. The receptor is believed to be activated by a wide variety of bitter compounds, including certain alkaloids, phenols, and polyphenols.

Structure

Like other members of the TAS2R family, TAS2R10 is a G protein-coupled receptor (GPCR). These receptors have seven transmembrane domains and are coupled to G proteins, which activate intracellular signaling pathways when the receptor is bound by a ligand.

Clinical significance

Variations in the TAS2R10 gene have been associated with differences in individual sensitivity to bitter tastes. This can influence dietary choices and may have implications for health. For example, individuals with certain TAS2R10 variants may be more likely to consume bitter-tasting foods and beverages, such as certain vegetables and coffee, which can have health benefits.

See also

• Taste receptor
• Bitter taste receptor
• G protein-coupled receptor

References

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TAS2R10

• Structure of a G protein-coupled receptor (GPCR)
  Structure of a G protein-coupled receptor (GPCR)
• Strychnos nux-vomica plant
  Strychnos nux-vomica plant