TAAR1

TAAR1 (Trace Amine-Associated Receptor 1) is a protein that in humans is encoded by the TAAR1 gene. TAAR1 is a high-affinity receptor for trace amines, a class of amines that are found in low levels in mammalian systems, but have significant physiological effects.

Function

TAAR1 is a G protein-coupled receptor (GPCR) that is expressed in the brain and peripheral tissues of humans and other mammals. It is thought to play a role in the regulation of neurotransmitter systems, including dopamine, serotonin, and norepinephrine. TAAR1 activation has been shown to reduce the activity of these neurotransmitter systems, suggesting a potential role in the treatment of psychiatric disorders such as schizophrenia, depression, and substance abuse.

Clinical significance

Several studies have suggested that TAAR1 may be a promising target for the treatment of a variety of psychiatric disorders. For example, TAAR1 agonists have been shown to have antipsychotic effects in animal models of schizophrenia, and to reduce drug-seeking behavior in models of addiction. In addition, TAAR1 antagonists have been shown to have antidepressant effects in animal models of depression.

See also

• Trace amine
• G protein-coupled receptor
• Neurotransmitter
• Schizophrenia
• Depression
• Substance abuse

References

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External links

• TAAR1 at WikiMD

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  Organ-specific expression and function of TAAR1