Delta-sleep-inducing peptide: Difference between revisions
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{{DISPLAYTITLE:Delta-sleep-inducing peptide}} | |||
== | == Delta-sleep-inducing peptide == | ||
[[File:DSIP_Structure.svg|thumb|right|Chemical structure of Delta-sleep-inducing peptide]] | |||
DSIP is | '''Delta-sleep-inducing peptide''' ('''DSIP''') is a [[neuropeptide]] that has been associated with sleep regulation and various physiological functions. It was first isolated in 1977 from the [[cerebrospinal fluid]] of rabbits. DSIP is a nonapeptide with the amino acid sequence [[Trp]]-[[Ala]]-[[Gly]]-[[Gly]]-[[Asp]]-[[Ala]]-[[Ser]]-[[Gly]]-[[Glu]]. | ||
== Structure and Properties == | |||
DSIP is a small peptide consisting of nine [[amino acids]]. Its structure is characterized by a sequence that allows it to interact with various [[receptor]]s in the [[central nervous system]]. The peptide is known for its ability to cross the [[blood-brain barrier]], which is crucial for its function in modulating sleep. | |||
== | == Function == | ||
DSIP is primarily known for its role in promoting [[sleep]], particularly [[slow-wave sleep]] or delta sleep. It is believed to influence the [[sleep-wake cycle]] by interacting with [[neurotransmitter]] systems, including the [[serotonin]]ergic and [[GABA]]ergic systems. In addition to its sleep-inducing properties, DSIP has been implicated in the regulation of [[endocrine]] functions, [[pain]] perception, and [[stress]] response. | |||
== Mechanism of Action == | |||
The exact mechanism by which DSIP induces sleep is not fully understood. However, it is thought to modulate the activity of [[hypothalamic]] and [[pituitary]] hormones, influencing the release of [[corticotropin]] and [[growth hormone]]. DSIP may also interact with [[opiate]] receptors, contributing to its analgesic effects. | |||
== | == Clinical Significance == | ||
Research into DSIP has explored its potential therapeutic applications in treating [[insomnia]], [[chronic pain]], and [[depression]]. However, clinical use is limited, and more studies are needed to fully understand its efficacy and safety. | |||
== Related Pages == | |||
* [[Neuropeptide]] | * [[Neuropeptide]] | ||
* [[Sleep]] | * [[Sleep]] | ||
* [[ | * [[Blood-brain barrier]] | ||
* [[ | * [[Endocrine system]] | ||
[[Category:Neuropeptides]] | [[Category:Neuropeptides]] | ||
[[Category:Sleep | [[Category:Sleep physiology]] | ||
Latest revision as of 06:37, 16 February 2025
Delta-sleep-inducing peptide[edit]
Delta-sleep-inducing peptide (DSIP) is a neuropeptide that has been associated with sleep regulation and various physiological functions. It was first isolated in 1977 from the cerebrospinal fluid of rabbits. DSIP is a nonapeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Structure and Properties[edit]
DSIP is a small peptide consisting of nine amino acids. Its structure is characterized by a sequence that allows it to interact with various receptors in the central nervous system. The peptide is known for its ability to cross the blood-brain barrier, which is crucial for its function in modulating sleep.
Function[edit]
DSIP is primarily known for its role in promoting sleep, particularly slow-wave sleep or delta sleep. It is believed to influence the sleep-wake cycle by interacting with neurotransmitter systems, including the serotoninergic and GABAergic systems. In addition to its sleep-inducing properties, DSIP has been implicated in the regulation of endocrine functions, pain perception, and stress response.
Mechanism of Action[edit]
The exact mechanism by which DSIP induces sleep is not fully understood. However, it is thought to modulate the activity of hypothalamic and pituitary hormones, influencing the release of corticotropin and growth hormone. DSIP may also interact with opiate receptors, contributing to its analgesic effects.
Clinical Significance[edit]
Research into DSIP has explored its potential therapeutic applications in treating insomnia, chronic pain, and depression. However, clinical use is limited, and more studies are needed to fully understand its efficacy and safety.
