Perrottetinene: Difference between revisions

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'''Perrottetinene''' is a naturally occurring cannabinoid compound found in the liverwort plant species ''Radula marginata'' and ''Radula perrottetii''. It is structurally similar to [[tetrahydrocannabinol]] (THC), the active compound in [[cannabis]], and has been found to have similar psychoactive effects in mice.
== Perrottetinene ==


== History ==
[[File:Perrottetinene.svg|thumb|right|Chemical structure of Perrottetinene]]


Perrottetinene was first isolated and identified in 1994 by a team of Japanese researchers led by Yoshinori Asakawa. The compound was named after the Swiss botanist [[G.A.W. Perrottet]], who first collected samples of ''Radula perrottetii'' in the 19th century.
'''Perrottetinene''' is a naturally occurring cannabinoid found in the liverwort species ''[[Radula perrottetii]]''. It is structurally similar to [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. Perrottetinene has been the subject of scientific interest due to its potential pharmacological effects and its unique presence in non-cannabis plants.


== Structure and properties ==
== Chemical Structure ==


Perrottetinene is a [[terpenoid]] compound, meaning it is derived from isoprene units. It is structurally similar to THC, with the main difference being the presence of a furan ring instead of a pyran ring. This structural similarity is thought to be responsible for the compound's psychoactive effects.
Perrottetinene is a [[terpenoid]] compound, characterized by its bicyclic structure. The chemical structure of perrottetinene includes a [[phenolic]] group, which is also present in THC, contributing to its similar pharmacological properties. The molecular formula of perrottetinene is C21H30O2.


== Biological effects ==
== Pharmacology ==


In 2018, a study published in the journal ''Science Advances'' reported that perrottetinene has psychoactive effects in mice. The study found that the compound activates the same [[cannabinoid receptors]] in the brain as THC, and has anti-inflammatory and analgesic effects. However, the study also noted that the effects of perrottetinene are less potent than those of THC.
Perrottetinene interacts with the [[endocannabinoid system]] in a manner similar to THC, binding to the [[cannabinoid receptor]]s CB1 and CB2. This interaction is responsible for its psychoactive effects. However, studies suggest that perrottetinene may have a lower affinity for these receptors compared to THC, potentially resulting in milder psychoactive effects.


== Legal status ==
== Natural Occurrence ==


As of 2021, perrottetinene is not specifically regulated under international drug control conventions. However, it may be considered a controlled substance in some jurisdictions under analogue laws.
Perrottetinene is found in the liverwort ''Radula perrottetii'', a plant native to New Zealand and Tasmania. This discovery is significant as it represents one of the few known instances of cannabinoids occurring outside the [[Cannabaceae]] family. The presence of perrottetinene in liverworts suggests a convergent evolution of cannabinoid biosynthesis in different plant lineages.


== See also ==
== Potential Applications ==
 
Research into perrottetinene is ongoing, with interest in its potential therapeutic applications. Its interaction with the endocannabinoid system suggests possible uses in pain management, anti-inflammatory treatments, and neuroprotection. However, more research is needed to fully understand its efficacy and safety profile.
 
== Related Pages ==


* [[Cannabinoid]]
* [[Cannabinoid]]
* [[Cannabis (drug)]]
* [[Tetrahydrocannabinol]]
* [[Radula marginata]]
* [[Endocannabinoid system]]
* [[Radula perrottetii]]
* [[Radula perrottetii]]
== References ==
<references />


[[Category:Cannabinoids]]
[[Category:Cannabinoids]]
[[Category:Psychoactive drugs]]
[[Category:Terpenoids]]
[[Category:Natural phenols]]
[[Category:Phytochemicals]]
[[Category:Terpenes and terpenoids]]
 
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Latest revision as of 11:40, 15 February 2025

Perrottetinene[edit]

Chemical structure of Perrottetinene

Perrottetinene is a naturally occurring cannabinoid found in the liverwort species Radula perrottetii. It is structurally similar to tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Perrottetinene has been the subject of scientific interest due to its potential pharmacological effects and its unique presence in non-cannabis plants.

Chemical Structure[edit]

Perrottetinene is a terpenoid compound, characterized by its bicyclic structure. The chemical structure of perrottetinene includes a phenolic group, which is also present in THC, contributing to its similar pharmacological properties. The molecular formula of perrottetinene is C21H30O2.

Pharmacology[edit]

Perrottetinene interacts with the endocannabinoid system in a manner similar to THC, binding to the cannabinoid receptors CB1 and CB2. This interaction is responsible for its psychoactive effects. However, studies suggest that perrottetinene may have a lower affinity for these receptors compared to THC, potentially resulting in milder psychoactive effects.

Natural Occurrence[edit]

Perrottetinene is found in the liverwort Radula perrottetii, a plant native to New Zealand and Tasmania. This discovery is significant as it represents one of the few known instances of cannabinoids occurring outside the Cannabaceae family. The presence of perrottetinene in liverworts suggests a convergent evolution of cannabinoid biosynthesis in different plant lineages.

Potential Applications[edit]

Research into perrottetinene is ongoing, with interest in its potential therapeutic applications. Its interaction with the endocannabinoid system suggests possible uses in pain management, anti-inflammatory treatments, and neuroprotection. However, more research is needed to fully understand its efficacy and safety profile.

Related Pages[edit]