JNJ-28330835: Difference between revisions

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'''JNJ-28330835''' is a [[pharmaceutical drug]] candidate that was developed by [[Johnson & Johnson]]. It is a [[selective androgen receptor modulator]] (SARM) that was investigated for potential therapeutic applications, but its development was discontinued before it reached the market.
{{DISPLAYTITLE:JNJ-28330835}}


== History ==
== Overview ==
'''JNJ-28330835''' is a chemical compound that has been studied for its potential therapeutic effects in various medical conditions. It is primarily known for its role as a [[kinase inhibitor]], which makes it a candidate for the treatment of diseases where kinase activity is dysregulated.


JNJ-28330835 was developed by the pharmaceutical company [[Johnson & Johnson]]. The company is known for its wide range of healthcare products, including pharmaceutical drugs, medical devices, and consumer packaged goods. JNJ-28330835 was one of the many drug candidates that the company has developed over the years.
== Chemical Structure ==
[[File:JNJ-28330835_structure.png|thumb|right|Chemical structure of JNJ-28330835]]
The chemical structure of JNJ-28330835 is characterized by its complex arrangement of atoms, which includes multiple rings and functional groups. This structure is crucial for its activity as a kinase inhibitor, allowing it to interact with specific [[enzyme]] targets in the body.


== Pharmacology ==
== Mechanism of Action ==
JNJ-28330835 functions by inhibiting the activity of certain [[protein kinases]], which are enzymes that modify other proteins by chemically adding phosphate groups. This inhibition can disrupt signaling pathways that are often overactive in diseases such as [[cancer]] and [[inflammatory disorders]]. By blocking these pathways, JNJ-28330835 can potentially halt the progression of these diseases.


JNJ-28330835 is a [[selective androgen receptor modulator]] (SARM). SARMs are a class of therapeutic compounds that have similar properties to [[anabolic steroids]], but with reduced androgenic properties. This property allows SARMs to benefit from the specificity of androgen receptor (AR) action in muscle and bone, while limiting the impact on other tissues, thus helping to reduce potential side effects.
== Potential Therapeutic Applications ==
The primary focus of research on JNJ-28330835 has been its application in oncology. As a kinase inhibitor, it has shown promise in preclinical studies for the treatment of various types of cancer, including [[breast cancer]], [[lung cancer]], and [[leukemia]]. Additionally, its anti-inflammatory properties suggest potential use in treating [[autoimmune diseases]] and other inflammatory conditions.


== Clinical Development ==
== Pharmacokinetics ==
The pharmacokinetic profile of JNJ-28330835 includes its absorption, distribution, metabolism, and excretion in the body. Understanding these properties is essential for determining the appropriate dosing regimens and predicting potential side effects. Studies have shown that JNJ-28330835 is metabolized primarily in the liver and excreted through the kidneys.


The clinical development of JNJ-28330835 was discontinued before it reached the market. The reasons for the discontinuation are not publicly disclosed, but it is common for drug candidates to be discontinued during development due to factors such as unfavorable results in preclinical or clinical trials, strategic decisions by the developing company, or potential safety concerns.
== Safety and Efficacy ==
Clinical trials are necessary to establish the safety and efficacy of JNJ-28330835 in humans. Preclinical studies have provided valuable insights into its potential benefits and risks, but further research is needed to confirm these findings in clinical settings. Common side effects observed in studies include [[nausea]], [[fatigue]], and [[diarrhea]].


== See Also ==
== Related Pages ==
* [[Kinase inhibitor]]
* [[Cancer treatment]]
* [[Pharmacokinetics]]
* [[Drug development]]


* [[Selective androgen receptor modulator]]
[[Category:Pharmacology]]
* [[Johnson & Johnson]]
[[Category:Experimental drugs]]
* [[Pharmaceutical drug]]
 
[[Category:Pharmaceutical drugs]]
[[Category:Selective androgen receptor modulators]]
[[Category:Johnson & Johnson]]
{{pharma-stub}}

Latest revision as of 11:16, 15 February 2025


Overview[edit]

JNJ-28330835 is a chemical compound that has been studied for its potential therapeutic effects in various medical conditions. It is primarily known for its role as a kinase inhibitor, which makes it a candidate for the treatment of diseases where kinase activity is dysregulated.

Chemical Structure[edit]

Chemical structure of JNJ-28330835

The chemical structure of JNJ-28330835 is characterized by its complex arrangement of atoms, which includes multiple rings and functional groups. This structure is crucial for its activity as a kinase inhibitor, allowing it to interact with specific enzyme targets in the body.

Mechanism of Action[edit]

JNJ-28330835 functions by inhibiting the activity of certain protein kinases, which are enzymes that modify other proteins by chemically adding phosphate groups. This inhibition can disrupt signaling pathways that are often overactive in diseases such as cancer and inflammatory disorders. By blocking these pathways, JNJ-28330835 can potentially halt the progression of these diseases.

Potential Therapeutic Applications[edit]

The primary focus of research on JNJ-28330835 has been its application in oncology. As a kinase inhibitor, it has shown promise in preclinical studies for the treatment of various types of cancer, including breast cancer, lung cancer, and leukemia. Additionally, its anti-inflammatory properties suggest potential use in treating autoimmune diseases and other inflammatory conditions.

Pharmacokinetics[edit]

The pharmacokinetic profile of JNJ-28330835 includes its absorption, distribution, metabolism, and excretion in the body. Understanding these properties is essential for determining the appropriate dosing regimens and predicting potential side effects. Studies have shown that JNJ-28330835 is metabolized primarily in the liver and excreted through the kidneys.

Safety and Efficacy[edit]

Clinical trials are necessary to establish the safety and efficacy of JNJ-28330835 in humans. Preclinical studies have provided valuable insights into its potential benefits and risks, but further research is needed to confirm these findings in clinical settings. Common side effects observed in studies include nausea, fatigue, and diarrhea.

Related Pages[edit]