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'''Dengue Vaccine''' is a vaccine used to prevent [[Dengue fever]], a mosquito-borne tropical disease caused by the [[dengue virus]]. Dengue fever is a significant cause of illness and death in the tropics and subtropics, with over 2.5 billion people at risk for the disease worldwide.
== Dengue Vaccine ==


== History ==
[[File:Qdenga_10-dose_carton.jpg|thumb|right|Qdenga 10-dose carton]]


The development of a [[Dengue Vaccine|dengue vaccine]] has been a public health priority for many years. The first dengue vaccine, Dengvaxia (CYD-TDV) by Sanofi Pasteur, was first licensed in 2015 and has been introduced in the national immunization programs of several countries.
The '''dengue vaccine''' is a vaccine used to prevent [[dengue fever]] in humans. Dengue fever is a mosquito-borne tropical disease caused by the [[dengue virus]]. The vaccine is particularly important in areas where dengue is endemic, as it can significantly reduce the incidence of the disease and its associated complications.


== Types of Dengue Vaccines ==
== Types of Dengue Vaccines ==


There are several types of dengue vaccines that are in various stages of development. These include:
There are several types of dengue vaccines that have been developed or are in development. These include:


* '''[[Dengvaxia]]''' (CYD-TDV) by Sanofi Pasteur
* '''Live attenuated vaccines''': These vaccines use a weakened form of the virus to stimulate an immune response without causing the disease.
* '''[[TAK-003]]''' by Takeda Pharmaceutical Company
* '''Inactivated vaccines''': These vaccines use a virus that has been killed, so it cannot cause disease, but can still provoke an immune response.
* '''[[TV003/TV005]]''' by the U.S. National Institutes of Health
* '''Subunit vaccines''': These vaccines use only parts of the virus, such as proteins, to stimulate an immune response.
* '''[[DENVax]]''' by Panacea Biotec
* '''DNA vaccines''': These vaccines use genetically engineered DNA to produce an immune response.


== Efficacy and Safety ==
== Qdenga Vaccine ==


The efficacy and safety of dengue vaccines are still under study. The World Health Organization (WHO) recommends the use of the Dengvaxia vaccine in individuals aged 9-45 years living in areas where dengue is endemic and who have confirmed previous dengue virus infection.
[[File:Qdenga_10-dose_carton.jpg|thumb|left|Qdenga vaccine packaging]]


== Side Effects ==
Qdenga is one of the dengue vaccines that has been developed to combat the disease. It is a live attenuated tetravalent vaccine, meaning it is designed to protect against all four serotypes of the dengue virus. The vaccine is administered in a series of doses and is intended for use in individuals living in or traveling to areas where dengue is common.


Like all vaccines, dengue vaccines can cause side effects, although not everybody gets them. The most common side effects are mild and include pain at the injection site, headache, and mild fever.
== Mechanism of Action ==


== Future Research ==
The dengue vaccine works by stimulating the body's immune system to produce antibodies against the dengue virus. When a vaccinated person is later exposed to the virus, their immune system can recognize and fight the virus more effectively, reducing the severity of the disease or preventing it altogether.


Future research on dengue vaccines focuses on improving the efficacy and safety of the vaccines, as well as developing vaccines that can provide protection against all four dengue virus serotypes.
== Challenges and Considerations ==


== See Also ==
Developing a dengue vaccine is challenging due to the presence of four distinct serotypes of the virus. A vaccine must provide immunity against all four serotypes to be effective. Additionally, there is a risk of [[antibody-dependent enhancement]] (ADE), where a person who has been vaccinated or previously infected with one serotype may experience more severe disease if infected with a different serotype.
 
== Related Pages ==


* [[Dengue fever]]
* [[Dengue fever]]
* [[Dengue virus]]
* [[Vaccine]]
* [[Vaccine]]
* [[Dengue virus]]
* [[Mosquito-borne diseases]]
* [[World Health Organization]]
 
== References ==
 
<references />


[[Category:Vaccines]]
[[Category:Vaccines]]
[[Category:Dengue fever]]
[[Category:Dengue]]
[[Category:Medical treatments]]
[[Category:Infectious disease control]]
[[Category:Immunology]]
 
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Latest revision as of 11:13, 15 February 2025

Dengue Vaccine[edit]

Qdenga 10-dose carton

The dengue vaccine is a vaccine used to prevent dengue fever in humans. Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. The vaccine is particularly important in areas where dengue is endemic, as it can significantly reduce the incidence of the disease and its associated complications.

Types of Dengue Vaccines[edit]

There are several types of dengue vaccines that have been developed or are in development. These include:

  • Live attenuated vaccines: These vaccines use a weakened form of the virus to stimulate an immune response without causing the disease.
  • Inactivated vaccines: These vaccines use a virus that has been killed, so it cannot cause disease, but can still provoke an immune response.
  • Subunit vaccines: These vaccines use only parts of the virus, such as proteins, to stimulate an immune response.
  • DNA vaccines: These vaccines use genetically engineered DNA to produce an immune response.

Qdenga Vaccine[edit]

Qdenga vaccine packaging

Qdenga is one of the dengue vaccines that has been developed to combat the disease. It is a live attenuated tetravalent vaccine, meaning it is designed to protect against all four serotypes of the dengue virus. The vaccine is administered in a series of doses and is intended for use in individuals living in or traveling to areas where dengue is common.

Mechanism of Action[edit]

The dengue vaccine works by stimulating the body's immune system to produce antibodies against the dengue virus. When a vaccinated person is later exposed to the virus, their immune system can recognize and fight the virus more effectively, reducing the severity of the disease or preventing it altogether.

Challenges and Considerations[edit]

Developing a dengue vaccine is challenging due to the presence of four distinct serotypes of the virus. A vaccine must provide immunity against all four serotypes to be effective. Additionally, there is a risk of antibody-dependent enhancement (ADE), where a person who has been vaccinated or previously infected with one serotype may experience more severe disease if infected with a different serotype.

Related Pages[edit]