Hypoblast: Difference between revisions

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'''Hypoblast''' is a layer of cells that, during the development of an embryo, forms the endoderm. The endoderm is one of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer), with the endoderm being the innermost layer.
{{Short description|An article about the hypoblast in embryonic development}}


==Formation==
==Hypoblast==
The hypoblast is formed during the process of gastrulation. Gastrulation is a phase early in the embryonic development of most animals, during which the single-layered blastula is reorganized into a multilayered structure known as the gastrula. The hypoblast cells migrate along the inner surface of the [[cytotrophoblast]] layer, displacing the [[epiblast]] cells and forming a layer beneath them.
The '''hypoblast''' is a layer of cells that forms during the early stages of [[embryonic development]] in [[vertebrates]]. It is one of the two layers that make up the [[bilaminar disc]], the other being the [[epiblast]]. The hypoblast plays a crucial role in the formation of the [[extraembryonic endoderm]] and contributes to the development of the [[yolk sac]].


==Function==
[[File:Human_Embryo_Day9.png|thumb|right|Human embryo at day 9, showing the hypoblast.]]
The hypoblast contributes to the formation of the [[embryo]] and extraembryonic tissues. It forms the yolk sac, which provides nutrients to the developing embryo, and also contributes to the formation of the gut. The hypoblast also plays a role in the formation of the amnion, the membrane that surrounds and protects the embryo.


==Clinical Significance==
===Formation===
Abnormalities in the formation of the hypoblast can lead to developmental disorders. For example, an incomplete formation of the hypoblast can result in a lack of certain organs or tissues, such as the gut or yolk sac.
The hypoblast forms during the second week of development, following the implantation of the [[blastocyst]] into the [[uterine wall]]. Initially, the inner cell mass of the blastocyst differentiates into two layers: the epiblast and the hypoblast. The hypoblast is situated beneath the epiblast and faces the [[blastocoel]].


==See Also==
===Function===
The primary function of the hypoblast is to contribute to the formation of the [[yolk sac]], which is an essential structure for nutrient transfer during early development. The hypoblast cells migrate to line the blastocoel, forming the [[Heuser's membrane]], which eventually becomes part of the yolk sac.
 
===Role in Development===
Although the hypoblast does not directly contribute to the formation of the [[embryo proper]], it plays an indirect role in embryonic patterning. The hypoblast helps to establish the [[anterior-posterior axis]] of the embryo by influencing the positioning of the [[primitive streak]] on the epiblast.
 
===Hypoblast and Gastrulation===
During [[gastrulation]], the hypoblast is displaced by the migrating epiblast cells that form the [[definitive endoderm]]. The hypoblast cells are eventually pushed to the periphery and contribute to the extraembryonic tissues.
 
==Related pages==
* [[Epiblast]]
* [[Gastrulation]]
* [[Gastrulation]]
* [[Embryogenesis]]
* [[Yolk sac]]
* [[Endoderm]]
* [[Embryonic development]]
* [[Epiblast]]
* [[Cytotrophoblast]]
 
==References==
<references />


[[Category:Embryology]]
[[Category:Embryology]]
[[Category:Developmental biology]]
[[Category:Cell biology]]
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Latest revision as of 10:56, 15 February 2025

An article about the hypoblast in embryonic development


Hypoblast[edit]

The hypoblast is a layer of cells that forms during the early stages of embryonic development in vertebrates. It is one of the two layers that make up the bilaminar disc, the other being the epiblast. The hypoblast plays a crucial role in the formation of the extraembryonic endoderm and contributes to the development of the yolk sac.

Human embryo at day 9, showing the hypoblast.

Formation[edit]

The hypoblast forms during the second week of development, following the implantation of the blastocyst into the uterine wall. Initially, the inner cell mass of the blastocyst differentiates into two layers: the epiblast and the hypoblast. The hypoblast is situated beneath the epiblast and faces the blastocoel.

Function[edit]

The primary function of the hypoblast is to contribute to the formation of the yolk sac, which is an essential structure for nutrient transfer during early development. The hypoblast cells migrate to line the blastocoel, forming the Heuser's membrane, which eventually becomes part of the yolk sac.

Role in Development[edit]

Although the hypoblast does not directly contribute to the formation of the embryo proper, it plays an indirect role in embryonic patterning. The hypoblast helps to establish the anterior-posterior axis of the embryo by influencing the positioning of the primitive streak on the epiblast.

Hypoblast and Gastrulation[edit]

During gastrulation, the hypoblast is displaced by the migrating epiblast cells that form the definitive endoderm. The hypoblast cells are eventually pushed to the periphery and contribute to the extraembryonic tissues.

Related pages[edit]