Brilaroxazine: Difference between revisions

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'''Brilaroxazine''' is an [[atypical antipsychotic]] that is used in the treatment of [[schizophrenia]]. It was developed by [[Reviva Pharmaceuticals]] and was approved by the [[Food and Drug Administration|FDA]] in the United States in 2020.
== Brilaroxazine ==


== History ==
[[File:Brilaroxazine.svg|thumb|right|Chemical structure of Brilaroxazine]]
Brilaroxazine was first developed by Reviva Pharmaceuticals, a company based in the United States. The drug was approved by the FDA in 2020 for the treatment of schizophrenia.


== Pharmacology ==
'''Brilaroxazine''' is a novel investigational drug that is being studied for its potential use in the treatment of [[schizophrenia]] and other [[neuropsychiatric disorders]]. It is classified as a [[serotonin receptor modulator]], specifically targeting multiple serotonin receptor subtypes, which are believed to play a role in the pathophysiology of these disorders.
Brilaroxazine is an atypical antipsychotic, which means it works differently than traditional antipsychotics. It is believed to work by blocking certain receptors in the brain, including [[dopamine receptor|dopamine]] and [[serotonin receptor|serotonin]] receptors. This can help to reduce the symptoms of schizophrenia.


== Uses ==
=== Mechanism of Action ===
Brilaroxazine is used to treat schizophrenia, a mental disorder that can cause hallucinations, delusions, and other cognitive difficulties. It can be used in adults as a standalone treatment or in combination with other medications.
Brilaroxazine acts as a modulator of several [[serotonin receptors]], including the 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub>, and 5-HT<sub>2B</sub> receptors. By influencing these receptors, brilaroxazine is thought to help balance neurotransmitter levels in the brain, which may alleviate symptoms associated with schizophrenia and other mental health conditions.


== Side Effects ==
=== Clinical Development ===
Like all medications, brilaroxazine can cause side effects. These can include drowsiness, dizziness, and weight gain. In rare cases, it can cause serious side effects like tardive dyskinesia, a condition that causes uncontrollable movements.
Brilaroxazine is currently undergoing clinical trials to evaluate its efficacy and safety in patients with schizophrenia. These trials are designed to assess the drug's impact on both positive and negative symptoms of the disorder, as well as its overall tolerability.


== See Also ==
=== Potential Benefits ===
* [[Atypical antipsychotic]]
The development of brilaroxazine is driven by the need for new treatments that offer improved efficacy and fewer side effects compared to existing antipsychotic medications. Its unique mechanism of action may provide benefits in terms of symptom control and patient quality of life.
 
=== Side Effects ===
As with any investigational drug, the side effects of brilaroxazine are being closely monitored in clinical trials. Common side effects observed in early studies include mild gastrointestinal disturbances and transient headache. However, comprehensive safety data will be available upon the completion of ongoing trials.
 
== Related Pages ==
* [[Schizophrenia]]
* [[Schizophrenia]]
* [[Reviva Pharmaceuticals]]
* [[Serotonin receptor]]
* [[Food and Drug Administration]]
* [[Antipsychotic]]
* [[Neurotransmitter]]


[[Category:Drugs]]
[[Category:Antipsychotics]]
[[Category:Antipsychotics]]
[[Category:Schizophrenia]]
[[Category:Investigational drugs]]
 
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== References ==
<references />
 
== External Links ==
* [https://www.revivapharma.com/ Reviva Pharmaceuticals]
* [https://www.fda.gov/ Food and Drug Administration]
 
== Further Reading ==
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165223/ "Brilaroxazine: A New Atypical Antipsychotic Drug for the Treatment of Schizophrenia"]
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Latest revision as of 10:47, 15 February 2025

Brilaroxazine[edit]

Chemical structure of Brilaroxazine

Brilaroxazine is a novel investigational drug that is being studied for its potential use in the treatment of schizophrenia and other neuropsychiatric disorders. It is classified as a serotonin receptor modulator, specifically targeting multiple serotonin receptor subtypes, which are believed to play a role in the pathophysiology of these disorders.

Mechanism of Action[edit]

Brilaroxazine acts as a modulator of several serotonin receptors, including the 5-HT1A, 5-HT2A, and 5-HT2B receptors. By influencing these receptors, brilaroxazine is thought to help balance neurotransmitter levels in the brain, which may alleviate symptoms associated with schizophrenia and other mental health conditions.

Clinical Development[edit]

Brilaroxazine is currently undergoing clinical trials to evaluate its efficacy and safety in patients with schizophrenia. These trials are designed to assess the drug's impact on both positive and negative symptoms of the disorder, as well as its overall tolerability.

Potential Benefits[edit]

The development of brilaroxazine is driven by the need for new treatments that offer improved efficacy and fewer side effects compared to existing antipsychotic medications. Its unique mechanism of action may provide benefits in terms of symptom control and patient quality of life.

Side Effects[edit]

As with any investigational drug, the side effects of brilaroxazine are being closely monitored in clinical trials. Common side effects observed in early studies include mild gastrointestinal disturbances and transient headache. However, comprehensive safety data will be available upon the completion of ongoing trials.

Related Pages[edit]