3-HO-PCP: Difference between revisions

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{{Short description|A dissociative anesthetic drug}}
{{DISPLAYTITLE:3-HO-PCP}}
{{Drugbox
| verifiedrevid = 477318870
| IUPAC_name = 3-Hydroxyphencyclidine
| image = 3-HO-PCP.svg
| width = 200
| legal_status = Uncontrolled
| routes_of_administration = Oral, Intranasal, Intravenous
| CAS_number = 79778-41-9
| PubChem = 44349643
| ChemSpiderID = 23274898
| UNII = 0F4X3Q3K4S
| C=17
| H=25
| N=1
| O=1
| smiles = OC1=CC=CC(C2CCN(CC2)C3CC3)=C1
}}


'''3-HO-PCP''' (3-Hydroxyphencyclidine) is a [[dissociative anesthetic]] drug that is chemically related to [[phencyclidine]] (PCP). It is known for its potent [[NMDA receptor antagonist]] properties, which contribute to its dissociative effects.
== 3-HO-PCP ==


==Pharmacology==
[[File:3-HO-PCP.svg|thumb|right|Chemical structure of 3-HO-PCP]]
3-HO-PCP acts primarily as an [[NMDA receptor antagonist]], which means it inhibits the action of the [[N-methyl-D-aspartate receptor|NMDA receptor]], a subtype of [[glutamate receptor]]. This inhibition leads to a decrease in the excitatory neurotransmission in the brain, resulting in the characteristic dissociative effects.


The drug also exhibits activity at the [[sigma receptor]]s, which may contribute to its psychoactive effects. The precise mechanism of action at these receptors is not fully understood.
'''3-HO-PCP''' (3-Hydroxyphencyclidine) is a [[dissociative]] [[anesthetic]] of the [[arylcyclohexylamine]] class. It is a derivative of [[phencyclidine]] (PCP) and is known for its potent [[NMDA receptor]] antagonistic properties.


==Effects==
=== Chemical Structure ===
The effects of 3-HO-PCP are similar to those of other dissociative anesthetics such as [[ketamine]] and PCP. Users may experience:
3-HO-PCP is chemically related to PCP, with the addition of a hydroxyl group at the third position of the phenyl ring. This modification alters its pharmacological profile, potentially affecting its potency and duration of action.
* Dissociation
* Euphoria
* Hallucinations
* Altered perception of time and space
* Analgesia


At higher doses, 3-HO-PCP can cause more severe effects such as:
=== Pharmacology ===
* Motor impairment
3-HO-PCP acts primarily as an antagonist at the NMDA receptor, a type of [[glutamate receptor]] in the brain. This action is responsible for its dissociative effects, which can include [[hallucinations]], [[analgesia]], and [[anesthesia]].
* Confusion
* Agitation
* Psychosis


==Legal Status==
=== Effects ===
As of the current date, 3-HO-PCP is not specifically controlled under international drug control treaties. However, its legal status may vary by country, and it may be subject to analogue laws in jurisdictions where PCP or similar substances are controlled.
The effects of 3-HO-PCP are similar to those of other dissociatives, such as [[ketamine]] and PCP. Users may experience altered perceptions of reality, changes in sensory perception, and a sense of detachment from the environment and self. The compound can also produce [[euphoria]] and [[sedation]].


==Related Compounds==
=== Risks and Safety ===
3-HO-PCP is part of a class of compounds known as [[arylcyclohexylamines]], which includes other dissociative anesthetics such as:
As with other dissociative anesthetics, 3-HO-PCP carries risks of [[neurotoxicity]], [[psychosis]], and [[addiction]]. It is important to approach its use with caution, particularly due to its potency and the potential for unpredictable effects.
* [[Phencyclidine]] (PCP)
* [[Ketamine]]
* [[Methoxetamine]] (MXE)


==See also==
== Related pages ==
* [[Dissociative drug]]
* [[NMDA receptor antagonist]]
* [[Arylcyclohexylamine]]
 
==Related pages==
* [[Phencyclidine]]
* [[Phencyclidine]]
* [[Ketamine]]
* [[Ketamine]]
* [[Dissociative drug]]
* [[Dissociative drug]]
* [[NMDA receptor antagonist]]


[[Category:Dissociative drugs]]
[[Category:Dissociative drugs]]
[[Category:Arylcyclohexylamines]]
[[Category:Arylcyclohexylamines]]
[[Category:NMDA receptor antagonists]]

Latest revision as of 04:03, 13 February 2025


3-HO-PCP[edit]

Chemical structure of 3-HO-PCP

3-HO-PCP (3-Hydroxyphencyclidine) is a dissociative anesthetic of the arylcyclohexylamine class. It is a derivative of phencyclidine (PCP) and is known for its potent NMDA receptor antagonistic properties.

Chemical Structure[edit]

3-HO-PCP is chemically related to PCP, with the addition of a hydroxyl group at the third position of the phenyl ring. This modification alters its pharmacological profile, potentially affecting its potency and duration of action.

Pharmacology[edit]

3-HO-PCP acts primarily as an antagonist at the NMDA receptor, a type of glutamate receptor in the brain. This action is responsible for its dissociative effects, which can include hallucinations, analgesia, and anesthesia.

Effects[edit]

The effects of 3-HO-PCP are similar to those of other dissociatives, such as ketamine and PCP. Users may experience altered perceptions of reality, changes in sensory perception, and a sense of detachment from the environment and self. The compound can also produce euphoria and sedation.

Risks and Safety[edit]

As with other dissociative anesthetics, 3-HO-PCP carries risks of neurotoxicity, psychosis, and addiction. It is important to approach its use with caution, particularly due to its potency and the potential for unpredictable effects.

Related pages[edit]