JWH-164: Difference between revisions

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'''JWH-164''' is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a binding affinity of 9.0 nM at CB1 and 2.94 nM at CB2. JWH-164 was first synthesized by organic chemist John W. Huffman.
{{DISPLAYTITLE:JWH-164}}


==Chemistry==
== JWH-164 ==
[[File:JWH-164.svg|thumb|right|Chemical structure of JWH-164]]
'''JWH-164''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].


JWH-164 is part of the [[naphthoylindole]] family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[JWH-018]] and [[JWH-073]]. The compound is named after its creator, [[John W. Huffman]], an organic chemist who first synthesized these compounds for research purposes.
=== Chemical Properties ===
JWH-164 is characterized by its chemical structure, which includes a naphthoyl group attached to an indole core. This structure is similar to other compounds in the JWH series, named after the chemist [[John W. Huffman]], who first synthesized many of these compounds.


==Pharmacology==
=== Pharmacology ===
JWH-164 functions as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation.


JWH-164 acts as a full [[agonist]] at the [[CB1 receptor]] and the [[CB2 receptor]]. The CB1 receptor is primarily located in the brain, and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system. The binding affinity of JWH-164 is 9.0 nM at CB1 and 2.94 nM at CB2.
=== Legal Status ===
Due to its potential for abuse and lack of medical use, JWH-164, like many synthetic cannabinoids, is classified as a controlled substance in many jurisdictions. The legal status can vary significantly between countries and regions.


==Effects==
=== Synthesis ===
 
The synthesis of JWH-164 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful handling due to the potential hazards associated with the chemicals involved.
The effects of JWH-164 are similar to those of other synthetic cannabinoids and include [[euphoria]], [[relaxation]], and [[perceptual alterations]]. However, the exact effects can vary greatly depending on the individual and the dosage used.
 
==Legal Status==
 
The legal status of JWH-164 varies by country and region. In many places, it is classified as a controlled substance due to its potential for abuse and its psychoactive effects.
 
==See Also==


== Related pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[Endocannabinoid system]]
* [[John W. Huffman]]
* [[John W. Huffman]]
==References==
<references />


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Naphthoylindoles]]
[[Category:Chemical compounds]]
[[Category:CB1 agonists]]
[[Category:CB2 agonists]]
{{Pharma-stub}}

Latest revision as of 04:01, 13 February 2025


JWH-164[edit]

Chemical structure of JWH-164

JWH-164 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Properties[edit]

JWH-164 is characterized by its chemical structure, which includes a naphthoyl group attached to an indole core. This structure is similar to other compounds in the JWH series, named after the chemist John W. Huffman, who first synthesized many of these compounds.

Pharmacology[edit]

JWH-164 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, JWH-164, like many synthetic cannabinoids, is classified as a controlled substance in many jurisdictions. The legal status can vary significantly between countries and regions.

Synthesis[edit]

The synthesis of JWH-164 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful handling due to the potential hazards associated with the chemicals involved.

Related pages[edit]