JWH-147: Difference between revisions

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'''JWH-147''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with a [[Ki]] of 0.69nM at CB1 and 1.8nM at CB2. It was discovered by and named after Dr. John W. Huffman.
== JWH-147 ==


==Chemistry==
[[File:JWH-147.svg|thumb|right|Chemical structure of JWH-147]]
JWH-147 is part of the naphthoylindole family of synthetic cannabinoids. It is a complex molecule with a molecular formula of C25H25NO2. The systematic name for JWH-147 is 1-pentyl-3-(2-methoxyphenylacetyl)indole.


==Pharmacology==
'''JWH-147''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].
JWH-147 acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors. The [[Ki]] values for this compound are 0.69nM at CB1 and 1.8nM at CB2. This makes it one of the most potent compounds in the JWH series.


==Effects==
=== Chemical Properties ===
The effects of JWH-147 are similar to those of other cannabinoids. They include relaxation, euphoria, altered perception, and in some cases, hallucinations. However, due to its potency, the effects of JWH-147 can be more intense and longer-lasting than those of natural cannabinoids.


==Legal Status==
JWH-147 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-147 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The presence of these groups contributes to its high affinity for cannabinoid receptors.
The legal status of JWH-147 varies by country. In some countries, it is classified as a controlled substance, while in others it is legal to possess and use.
 
=== Pharmacology ===
 
JWH-147 acts as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes including mood, appetite, and pain sensation. The activation of these receptors by JWH-147 can lead to effects similar to those produced by natural cannabinoids.
 
=== Effects and Usage ===
 
The effects of JWH-147 are similar to those of other synthetic cannabinoids, including euphoria, altered perception, and relaxation. However, due to its potency, the effects can be more intense and may include adverse reactions such as anxiety, paranoia, and tachycardia. JWH-147 and similar compounds have been used in research to study the [[endocannabinoid system]] and the effects of cannabinoid receptor activation.
 
=== Legal Status ===
 
The legal status of JWH-147 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. The regulation of synthetic cannabinoids like JWH-147 is part of broader efforts to control the distribution and use of designer drugs.
 
== Related Pages ==


==See Also==
* [[JWH-018]]
* [[JWH-073]]
* [[JWH-200]]
* [[Cannabinoid]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
 
* [[Synthetic cannabinoid]]
==References==
* [[Endocannabinoid system]]
<references />
* [[Naphthoylindole]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Naphthoylindoles]]
[[Category:Indoles]]
{{stub}}

Latest revision as of 03:58, 13 February 2025

JWH-147[edit]

Chemical structure of JWH-147

JWH-147 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Properties[edit]

JWH-147 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-147 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The presence of these groups contributes to its high affinity for cannabinoid receptors.

Pharmacology[edit]

JWH-147 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, and pain sensation. The activation of these receptors by JWH-147 can lead to effects similar to those produced by natural cannabinoids.

Effects and Usage[edit]

The effects of JWH-147 are similar to those of other synthetic cannabinoids, including euphoria, altered perception, and relaxation. However, due to its potency, the effects can be more intense and may include adverse reactions such as anxiety, paranoia, and tachycardia. JWH-147 and similar compounds have been used in research to study the endocannabinoid system and the effects of cannabinoid receptor activation.

Legal Status[edit]

The legal status of JWH-147 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. The regulation of synthetic cannabinoids like JWH-147 is part of broader efforts to control the distribution and use of designer drugs.

Related Pages[edit]