Tipepidine: Difference between revisions

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'''Tipepidine''' (''3,3-Diphenylpropylamine'') is a synthetic, non-opioid, centrally acting cough suppressant, or antitussive, that has been in use in Japan since 1959. It is most commonly found in the form of a syrup, combined with other ingredients such as [[Guaifenesin]] or [[Pseudoephedrine]], to treat symptoms of the common cold.
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== Tipepidine ==
[[File:Tipepidine.svg|thumb|right|Chemical structure of Tipepidine]]
'''Tipepidine''' is a [[cough suppressant]] medication that is used primarily in [[Japan]]. It is known for its antitussive properties and is often prescribed for the treatment of [[cough]] associated with [[respiratory tract infections]].


== Pharmacology ==
== Pharmacology ==
Tipepidine acts as a [[sigma receptor]] agonist, which is believed to contribute to its cough suppressant effects. Unlike many other cough suppressants, it does not act on the [[opioid receptor]]s, which reduces the risk of [[addiction]] and [[respiratory depression]].
=== Mechanism of Action ===
The exact mechanism by which tipepidine suppresses cough is not fully understood. However, it is thought to modulate the [[central nervous system]] by interacting with sigma receptors, which are involved in the regulation of [[neurotransmitter]] release and [[neuroplasticity]].


Tipepidine acts on the central nervous system (CNS) to suppress the cough reflex. While the exact mechanism of action is not fully understood, it is believed to involve modulation of the [[GABAergic]] system, similar to other non-opioid antitussives such as [[Dextromethorphan]] and [[Butamirate]].
== Clinical Use ==
Tipepidine is primarily used in the treatment of coughs associated with [[upper respiratory tract infections]]. It is available in various formulations, including [[syrup]]s and [[tablet]]s. The medication is generally well-tolerated, with a low incidence of side effects.


== Side Effects ==
== Side Effects ==
Common side effects of tipepidine may include mild [[drowsiness]], [[nausea]], and [[dizziness]]. Serious side effects are rare, making it a preferred choice for patients who require long-term cough management.


Common side effects of Tipepidine include drowsiness, nausea, and dizziness. In rare cases, it can cause hallucinations or other serious mental changes. As with all medications, it should be used under the supervision of a healthcare professional.
== History ==
 
Tipepidine was first developed in the 1950s and has been used in clinical practice in Japan for several decades. It has not been widely adopted outside of Japan, but it remains a popular choice for cough suppression in the region.
== Interactions ==
 
Tipepidine may interact with other CNS depressants, including alcohol, antihistamines, and sedatives, increasing the risk of side effects. It is also known to interact with [[Monoamine oxidase inhibitors]] (MAOIs), potentially leading to a hypertensive crisis.
 
== See Also ==
 
* [[Antitussive]]
* [[Cough medicine]]
* [[Dextromethorphan]]
* [[Butamirate]]
 
== References ==


<references />
== Related pages ==
* [[Cough suppressant]]
* [[Sigma receptor]]
* [[Respiratory tract infection]]


[[Category:Drugs]]
[[Category:Antitussives]]
[[Category:Antitussives]]
[[Category:Pharmacology]]
[[Category:Sigma receptor agonists]]
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Latest revision as of 03:55, 13 February 2025


Tipepidine[edit]

File:Tipepidine.svg
Chemical structure of Tipepidine

Tipepidine is a cough suppressant medication that is used primarily in Japan. It is known for its antitussive properties and is often prescribed for the treatment of cough associated with respiratory tract infections.

Pharmacology[edit]

Tipepidine acts as a sigma receptor agonist, which is believed to contribute to its cough suppressant effects. Unlike many other cough suppressants, it does not act on the opioid receptors, which reduces the risk of addiction and respiratory depression.

Mechanism of Action[edit]

The exact mechanism by which tipepidine suppresses cough is not fully understood. However, it is thought to modulate the central nervous system by interacting with sigma receptors, which are involved in the regulation of neurotransmitter release and neuroplasticity.

Clinical Use[edit]

Tipepidine is primarily used in the treatment of coughs associated with upper respiratory tract infections. It is available in various formulations, including syrups and tablets. The medication is generally well-tolerated, with a low incidence of side effects.

Side Effects[edit]

Common side effects of tipepidine may include mild drowsiness, nausea, and dizziness. Serious side effects are rare, making it a preferred choice for patients who require long-term cough management.

History[edit]

Tipepidine was first developed in the 1950s and has been used in clinical practice in Japan for several decades. It has not been widely adopted outside of Japan, but it remains a popular choice for cough suppression in the region.

Related pages[edit]