TC-1698: Difference between revisions

Latest revision as of 03:55, 13 February 2025

Overview[edit]

The human heart is a muscular organ responsible for pumping blood through the circulatory system. It is located in the thoracic cavity between the lungs and is roughly the size of a fist. The heart is composed of four chambers: two upper chambers called atria and two lower chambers called ventricles.

Structure[edit]

The heart is divided into the right and left sides, each with an atrium and a ventricle. The right side of the heart receives deoxygenated blood from the body and pumps it to the lungs for oxygenation, while the left side receives oxygenated blood from the lungs and pumps it to the rest of the body.

Chambers[edit]

Right Atrium: Receives deoxygenated blood from the superior vena cava, inferior vena cava, and coronary sinus.
Right Ventricle: Pumps deoxygenated blood to the lungs via the pulmonary artery.
Left Atrium: Receives oxygenated blood from the lungs through the pulmonary veins.
Left Ventricle: Pumps oxygenated blood to the body through the aorta.

Valves[edit]

The heart contains four main heart valves that ensure unidirectional blood flow:

Tricuspid Valve: Located between the right atrium and right ventricle.
Pulmonary Valve: Located between the right ventricle and pulmonary artery.
Mitral Valve: Located between the left atrium and left ventricle.
Aortic Valve: Located between the left ventricle and aorta.

Function[edit]

The primary function of the heart is to maintain blood circulation throughout the body. It achieves this through a coordinated sequence of contractions and relaxations known as the cardiac cycle. The heart's electrical conduction system, including the sinoatrial node, atrioventricular node, and Purkinje fibers, regulates the heartbeat.

Blood Supply[edit]

The heart muscle, or myocardium, receives its blood supply from the coronary arteries. These arteries branch off from the aorta and encircle the heart, providing oxygen and nutrients to the heart tissue.

Related pages[edit]

@@ Line 1: / Line 1: @@
-'''TC-1698''' is a [[drug]] that was developed for the treatment of [[neurological disorders]]. It is a [[nicotinic acetylcholine receptor]] agonist, specifically targeting the α4β2 subtype of this receptor. This subtype is one of the most common in the brain and is implicated in a number of neurological conditions.
+== Overview ==
-== History ==
+[[File:TC-1698.svg|thumb|right|Illustration of the human heart]]
+The human heart is a muscular organ responsible for pumping blood through the [[circulatory system]]. It is located in the [[thoracic cavity]] between the lungs and is roughly the size of a fist. The heart is composed of four chambers: two upper chambers called [[atria]] and two lower chambers called [[ventricles]].
-TC-1698 was developed by the pharmaceutical company [[Targacept]]. The company was founded in 1997 and has focused on the development of drugs targeting nicotinic acetylcholine receptors. TC-1698 was one of the drugs developed by the company, although it has not yet been approved for use in humans.
+== Structure ==
-== Mechanism of Action ==
+The heart is divided into the right and left sides, each with an atrium and a ventricle. The right side of the heart receives deoxygenated blood from the body and pumps it to the [[lungs]] for oxygenation, while the left side receives oxygenated blood from the lungs and pumps it to the rest of the body.
-TC-1698 works by binding to and activating the α4β2 subtype of the nicotinic acetylcholine receptor. This receptor is a type of [[ion channel]], which allows ions to flow across the cell membrane when it is activated. By activating this receptor, TC-1698 can increase the flow of ions across the cell membrane, which can have various effects on the cell's function.
+=== Chambers ===
-== Potential Uses ==
+* '''Right Atrium''': Receives deoxygenated blood from the [[superior vena cava]], [[inferior vena cava]], and [[coronary sinus]].
+* '''Right Ventricle''': Pumps deoxygenated blood to the lungs via the [[pulmonary artery]].
+* '''Left Atrium''': Receives oxygenated blood from the lungs through the [[pulmonary veins]].
+* '''Left Ventricle''': Pumps oxygenated blood to the body through the [[aorta]].
-Due to its mechanism of action, TC-1698 has potential uses in the treatment of various neurological disorders. These include [[Alzheimer's disease]], [[Parkinson's disease]], and [[schizophrenia]]. However, further research is needed to determine the effectiveness and safety of TC-1698 in treating these conditions.
+=== Valves ===
-== Clinical Trials ==
+The heart contains four main [[heart valves]] that ensure unidirectional blood flow:
-As of now, TC-1698 has undergone preclinical trials, which have shown promising results. However, it has not yet undergone clinical trials in humans. Therefore, it is not currently available for use in the treatment of any condition.
+* '''Tricuspid Valve''': Located between the right atrium and right ventricle.
+* '''Pulmonary Valve''': Located between the right ventricle and pulmonary artery.
+* '''Mitral Valve''': Located between the left atrium and left ventricle.
+* '''Aortic Valve''': Located between the left ventricle and aorta.
-== See Also ==
+== Function ==
-* [[Nicotinic acetylcholine receptor]]
+The primary function of the heart is to maintain [[blood circulation]] throughout the body. It achieves this through a coordinated sequence of [[cardiac cycle|contractions and relaxations]] known as the cardiac cycle. The heart's electrical conduction system, including the [[sinoatrial node]], [[atrioventricular node]], and [[Purkinje fibers]], regulates the heartbeat.
-* [[Targacept]]
-* [[Neurological disorders]]
-[[Category:Drugs]]
+== Blood Supply ==
-[[Category:Neurological disorders]]
-[[Category:Pharmaceuticals]]
+[[File:TC-1698.svg|thumb|left|Diagram showing the coronary arteries]]
-{{Pharma-stub}}
+The heart muscle, or [[myocardium]], receives its blood supply from the [[coronary arteries]]. These arteries branch off from the aorta and encircle the heart, providing oxygen and nutrients to the heart tissue.
-{{Medicine-stub}}
+== Related pages ==
+* [[Cardiovascular system]]
+* [[Electrocardiography]]
+* [[Heart disease]]
+* [[Cardiac muscle]]
+[[Category:Cardiology]]