Phlorizin: Difference between revisions
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{{Short description|A natural compound found in some plants, used in medical research}} | |||
== | ==Phlorizin== | ||
Phlorizin | [[File:Phlorhizin.svg|thumb|right|Chemical structure of Phlorizin]] | ||
'''Phlorizin''' (also known as '''phlorhizin''') is a [[natural compound]] found in the bark of [[apple trees]] and other fruit trees. It is a type of [[glucoside]] and is known for its role in the study of [[diabetes]] and [[renal physiology]]. | |||
== | ==Chemical Properties== | ||
Phlorizin is | Phlorizin is a [[glucoside]] of [[phloretin]], a dihydrochalcone. Its chemical formula is C<sub>21</sub>H<sub>24</sub>O<sub>10</sub>. The compound is characterized by its ability to inhibit the [[sodium-glucose transport proteins]] (SGLT1 and SGLT2), which are responsible for glucose reabsorption in the [[kidneys]]. | ||
== | ==Biological Role== | ||
Phlorizin | Phlorizin has been extensively studied for its effects on [[glucose metabolism]]. By inhibiting SGLT2, phlorizin prevents the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine. This property has made it a valuable tool in the study of [[diabetes mellitus]], particularly in understanding the mechanisms of [[glucosuria]]. | ||
== Medical | ==Medical Research== | ||
In medical research, phlorizin has been used to induce a state of [[artificial diabetes]] in animal models. This allows researchers to study the effects of diabetes and test potential treatments. The compound's ability to block glucose reabsorption has also inspired the development of [[SGLT2 inhibitors]], a class of [[antidiabetic drugs]] used to treat [[type 2 diabetes]]. | |||
== | ==Historical Context== | ||
Phlorizin was first isolated in the 19th century and has since played a significant role in the field of [[endocrinology]]. Its discovery contributed to the understanding of [[renal glucose transport]] and the development of therapeutic strategies for managing diabetes. | |||
== | ==Related Pages== | ||
* [[Glucoside]] | |||
* [[SGLT2 inhibitors]] | |||
* [[Diabetes mellitus]] | |||
* [[Renal physiology]] | |||
[[Category: | [[Category:Natural compounds]] | ||
[[Category:Glucosides]] | [[Category:Glucosides]] | ||
[[Category:Diabetes]] | [[Category:Diabetes research]] | ||
Latest revision as of 03:55, 13 February 2025
A natural compound found in some plants, used in medical research
Phlorizin[edit]
Phlorizin (also known as phlorhizin) is a natural compound found in the bark of apple trees and other fruit trees. It is a type of glucoside and is known for its role in the study of diabetes and renal physiology.
Chemical Properties[edit]
Phlorizin is a glucoside of phloretin, a dihydrochalcone. Its chemical formula is C21H24O10. The compound is characterized by its ability to inhibit the sodium-glucose transport proteins (SGLT1 and SGLT2), which are responsible for glucose reabsorption in the kidneys.
Biological Role[edit]
Phlorizin has been extensively studied for its effects on glucose metabolism. By inhibiting SGLT2, phlorizin prevents the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine. This property has made it a valuable tool in the study of diabetes mellitus, particularly in understanding the mechanisms of glucosuria.
Medical Research[edit]
In medical research, phlorizin has been used to induce a state of artificial diabetes in animal models. This allows researchers to study the effects of diabetes and test potential treatments. The compound's ability to block glucose reabsorption has also inspired the development of SGLT2 inhibitors, a class of antidiabetic drugs used to treat type 2 diabetes.
Historical Context[edit]
Phlorizin was first isolated in the 19th century and has since played a significant role in the field of endocrinology. Its discovery contributed to the understanding of renal glucose transport and the development of therapeutic strategies for managing diabetes.
