Cafestol: Difference between revisions

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'''Cafestol''' is a [[diterpene]] molecule present in [[coffee]]. A potent [[LDL cholesterol]] elevating compound, it is found in highest quantity in unfiltered coffee drinks. Studies have shown that cafestol affects the body's ability to metabolize and regulate cholesterol.
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==Cafestol==
[[File:Cafestol.svg|thumb|right|Chemical structure of cafestol]]
Cafestol is a diterpene molecule found in coffee beans. It is one of the compounds responsible for the characteristic flavor and aroma of coffee. Cafestol is also known for its potential effects on human health, particularly its impact on cholesterol levels.


==Chemical Structure==
==Chemical Structure==
Cafestol is a member of the diterpene family of organic compounds. It is structurally similar to other diterpenes, with a molecular formula of C20H28O3.
Cafestol is a diterpene, which is a type of hydrocarbon composed of four isoprene units. Its chemical formula is C\textsubscript{20}H\textsubscript{28}O\textsubscript{3}. The structure of cafestol includes a cyclopentane ring fused to a cyclohexene ring, with several methyl groups and a hydroxyl group attached.
 
==Sources==
Cafestol is primarily found in unfiltered coffee beverages, such as [[Turkish coffee]] and [[French press]] coffee. The compound is present in the oily fraction of coffee and is extracted during the brewing process. Filtered coffee, such as that made with a drip coffee maker, contains significantly lower amounts of cafestol because the paper filter traps the oily compounds.


==Health Effects==
==Health Effects==
Cafestol has been found to have both beneficial and harmful effects on health. It has been shown to be a potent elevating agent of plasma [[cholesterol]] levels in humans. However, it also has potential anticarcinogenic properties, particularly in relation to [[colorectal cancer]].
Cafestol has been studied for its effects on [[cholesterol]] levels in humans. It is known to increase serum cholesterol by inhibiting bile acid synthesis, which leads to an increase in cholesterol levels in the blood. This effect is more pronounced in individuals who consume large amounts of unfiltered coffee.


===Cholesterol===
===Cholesterol===
Cafestol is one of the most potent cholesterol elevating compounds found in the human diet. It increases the levels of LDL cholesterol in the body by suppressing the activity of a liver receptor that regulates cholesterol levels.
Cafestol raises both [[low-density lipoprotein]] (LDL) and [[high-density lipoprotein]] (HDL) cholesterol levels. The increase in LDL cholesterol is of particular concern because it is associated with an increased risk of [[cardiovascular disease]].


===Cancer===
==Metabolism==
Studies have suggested that cafestol may have anticarcinogenic properties. It has been found to inhibit the growth of [[cancer cells]] in vitro and in animal models.
Cafestol is metabolized in the liver. It undergoes various transformations, including hydroxylation and conjugation, before being excreted from the body. The metabolism of cafestol can vary between individuals, which may influence its effects on cholesterol levels.


==Sources==
==Research==
Cafestol is found in the oily part of coffee, and is therefore present in higher amounts in unfiltered coffee drinks such as French press coffee or Turkish coffee. It is also found in espresso, but in lower amounts due to the filtering process.
Ongoing research is exploring the potential health benefits and risks associated with cafestol consumption. Some studies suggest that cafestol may have anti-inflammatory and anti-cancer properties, although more research is needed to confirm these effects.


==See Also==
==Related Pages==
* [[Coffee]]
* [[Coffee]]
* [[Cholesterol]]
* [[Diterpene]]
* [[Diterpene]]
* [[Cholesterol]]
* [[Cardiovascular disease]]
* [[Cancer]]


[[Category:Coffee]]
[[Category:Coffee]]
[[Category:Diterpenes]]
[[Category:Cholesterol]]
[[Category:Cholesterol]]
[[Category:Diterpenes]]
[[Category:Cancer]]
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Latest revision as of 03:36, 13 February 2025


Cafestol[edit]

Chemical structure of cafestol

Cafestol is a diterpene molecule found in coffee beans. It is one of the compounds responsible for the characteristic flavor and aroma of coffee. Cafestol is also known for its potential effects on human health, particularly its impact on cholesterol levels.

Chemical Structure[edit]

Cafestol is a diterpene, which is a type of hydrocarbon composed of four isoprene units. Its chemical formula is C\textsubscript{20}H\textsubscript{28}O\textsubscript{3}. The structure of cafestol includes a cyclopentane ring fused to a cyclohexene ring, with several methyl groups and a hydroxyl group attached.

Sources[edit]

Cafestol is primarily found in unfiltered coffee beverages, such as Turkish coffee and French press coffee. The compound is present in the oily fraction of coffee and is extracted during the brewing process. Filtered coffee, such as that made with a drip coffee maker, contains significantly lower amounts of cafestol because the paper filter traps the oily compounds.

Health Effects[edit]

Cafestol has been studied for its effects on cholesterol levels in humans. It is known to increase serum cholesterol by inhibiting bile acid synthesis, which leads to an increase in cholesterol levels in the blood. This effect is more pronounced in individuals who consume large amounts of unfiltered coffee.

Cholesterol[edit]

Cafestol raises both low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels. The increase in LDL cholesterol is of particular concern because it is associated with an increased risk of cardiovascular disease.

Metabolism[edit]

Cafestol is metabolized in the liver. It undergoes various transformations, including hydroxylation and conjugation, before being excreted from the body. The metabolism of cafestol can vary between individuals, which may influence its effects on cholesterol levels.

Research[edit]

Ongoing research is exploring the potential health benefits and risks associated with cafestol consumption. Some studies suggest that cafestol may have anti-inflammatory and anti-cancer properties, although more research is needed to confirm these effects.

Related Pages[edit]