Zeranol: Difference between revisions

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'''Zeranol''' is a non-steroidal [[estrogen]]ic compound used as a growth promoter in livestock, including beef cattle and sheep. It is a [[resorcylic acid lactone]] and a derivative of [[mycotoxin]] zearalenone, produced by the fungus ''[[Fusarium]]''.
{{DISPLAYTITLE:Zeranol}}


== History ==
==Zeranol==
Zeranol was first approved for use in the United States in 1969 by the [[Food and Drug Administration|FDA]]. It is marketed under the trade names Ralgro and Ralone.
[[File:Alpha_Zearalanol.svg|thumb|right|Chemical structure of Zeranol]]
Zeranol, also known as _-zearalanol, is a non-steroidal estrogenic compound used as a growth promoter in livestock. It is a mycotoxin derived from the fungus [[Fusarium]], which is commonly found in grains such as corn and wheat. Zeranol is a semi-synthetic derivative of [[zearalenone]], a naturally occurring estrogenic compound produced by the same fungus.


== Use in livestock ==
==Chemical Properties==
Zeranol is used as a growth promoter in livestock, particularly beef cattle and sheep. It is administered via a subcutaneous ear implant. The compound promotes growth by increasing the rate of weight gain and improving feed efficiency.
Zeranol is a resorcylic acid lactone, which is a class of compounds known for their estrogenic activity. Its chemical structure is similar to that of natural estrogens, allowing it to bind to estrogen receptors in the body. This binding can mimic the effects of estrogen, leading to increased growth rates in animals.


== Health effects ==
==Uses in Agriculture==
Zeranol has been shown to have estrogenic effects, which can lead to reproductive issues in animals. There is also concern about potential health effects in humans who consume meat from animals treated with zeranol, although the FDA maintains that the levels present in meat are safe for human consumption.
Zeranol is primarily used in the beef industry to promote growth and increase feed efficiency in cattle. It is administered as an implant placed under the skin of the ear, where it slowly releases the compound into the bloodstream. This practice is regulated in many countries to ensure that meat products are safe for human consumption.


== Regulation ==
==Mechanism of Action==
Zeranol is approved for use in livestock in the United States and several other countries. However, it is banned in the European Union due to concerns about potential health effects.
Zeranol acts by binding to estrogen receptors in the animal's body, which stimulates protein synthesis and muscle growth. This results in increased weight gain and improved feed conversion ratios. The compound's estrogenic activity is responsible for these effects, as it mimics the action of natural estrogens in promoting growth.


== See also ==
==Health and Safety==
* [[Growth hormone treatment]]
The use of zeranol in livestock has raised concerns about potential health risks to humans. Studies have investigated the possibility of zeranol residues in meat products and their effects on human health. Regulatory agencies have established maximum residue limits to ensure that meat is safe for consumption.
* [[Veterinary drug]]
* [[Food safety]]


== References ==
==Regulation==
<references />
The use of zeranol is regulated by various governmental agencies, including the [[Food and Drug Administration]] (FDA) in the United States and the [[European Food Safety Authority]] (EFSA) in the European Union. These agencies set guidelines for the safe use of zeranol in livestock and monitor compliance through testing and inspections.


==Environmental Impact==
The environmental impact of zeranol use in agriculture is a topic of ongoing research. Concerns include the potential for zeranol to enter water systems through runoff and its effects on wildlife. Studies are being conducted to assess the environmental persistence of zeranol and its metabolites.
==Related Pages==
* [[Zearalenone]]
* [[Estrogen]]
* [[Growth hormone]]
* [[Fusarium]]
[[Category:Mycotoxins]]
[[Category:Estrogens]]
[[Category:Veterinary drugs]]
[[Category:Veterinary drugs]]
[[Category:Growth hormones]]
[[Category:Estrogens]]
[[Category:Food safety]]
{{stub}}

Latest revision as of 03:34, 13 February 2025


Zeranol[edit]

Chemical structure of Zeranol

Zeranol, also known as _-zearalanol, is a non-steroidal estrogenic compound used as a growth promoter in livestock. It is a mycotoxin derived from the fungus Fusarium, which is commonly found in grains such as corn and wheat. Zeranol is a semi-synthetic derivative of zearalenone, a naturally occurring estrogenic compound produced by the same fungus.

Chemical Properties[edit]

Zeranol is a resorcylic acid lactone, which is a class of compounds known for their estrogenic activity. Its chemical structure is similar to that of natural estrogens, allowing it to bind to estrogen receptors in the body. This binding can mimic the effects of estrogen, leading to increased growth rates in animals.

Uses in Agriculture[edit]

Zeranol is primarily used in the beef industry to promote growth and increase feed efficiency in cattle. It is administered as an implant placed under the skin of the ear, where it slowly releases the compound into the bloodstream. This practice is regulated in many countries to ensure that meat products are safe for human consumption.

Mechanism of Action[edit]

Zeranol acts by binding to estrogen receptors in the animal's body, which stimulates protein synthesis and muscle growth. This results in increased weight gain and improved feed conversion ratios. The compound's estrogenic activity is responsible for these effects, as it mimics the action of natural estrogens in promoting growth.

Health and Safety[edit]

The use of zeranol in livestock has raised concerns about potential health risks to humans. Studies have investigated the possibility of zeranol residues in meat products and their effects on human health. Regulatory agencies have established maximum residue limits to ensure that meat is safe for consumption.

Regulation[edit]

The use of zeranol is regulated by various governmental agencies, including the Food and Drug Administration (FDA) in the United States and the European Food Safety Authority (EFSA) in the European Union. These agencies set guidelines for the safe use of zeranol in livestock and monitor compliance through testing and inspections.

Environmental Impact[edit]

The environmental impact of zeranol use in agriculture is a topic of ongoing research. Concerns include the potential for zeranol to enter water systems through runoff and its effects on wildlife. Studies are being conducted to assess the environmental persistence of zeranol and its metabolites.

Related Pages[edit]