PHI-base: Difference between revisions

Latest revision as of 03:33, 13 February 2025

A database of pathogen-host interactions

Overview[edit]

PHI-base (Pathogen-Host Interactions database) is a comprehensive online resource that catalogues experimentally verified pathogenicity, virulence, and effector genes from various pathogens. It serves as a critical tool for researchers studying the molecular mechanisms of infectious diseases and the interactions between pathogens and their hosts.

History[edit]

PHI-base was established to provide a centralized repository of information on pathogen-host interactions. It was developed to support the scientific community by offering access to curated data that can be used to understand the genetic basis of pathogenicity and host resistance.

Content[edit]

PHI-base contains detailed information on:

Pathogenicity genes: Genes that are essential for a pathogen to cause disease.
Virulence genes: Genes that enhance the severity of disease symptoms.
Effector genes: Genes that encode proteins or molecules that manipulate host cell processes.

The database includes data from a wide range of pathogens, including bacteria, fungi, oomycetes, and viruses, and their interactions with plant, animal, and human hosts.

Functionality[edit]

PHI-base provides several features to facilitate research:

Search and Browse: Users can search for specific genes, pathogens, or host species.
Data Export: Researchers can download data for further analysis.
Curation: The database is regularly updated with new findings from scientific literature.

Applications[edit]

PHI-base is used in various fields of research, including:

Agricultural Science: Understanding plant-pathogen interactions to develop disease-resistant crops.
Medical Research: Identifying potential targets for new antimicrobial drugs.
Epidemiology: Studying the spread and control of infectious diseases.

Related pages[edit]

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-'''PHI-base''' is a web-accessible database that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal, Oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. PHI-base is therapeutically relevant to researchers worldwide, aiding the identification of targets for chemical intervention. If a particular gene is essential for a pathogen's survival, knowledge of its structure can enable the design of chemical inhibitors, leading to disease control.
+{{Short description|A database of pathogen-host interactions}}
+{{Use dmy dates|date=October 2023}}
-== Overview ==
+==Overview==
+[[File:PHI-base_01.jpg|thumb|right|PHI-base logo]]
+'''PHI-base''' (Pathogen-Host Interactions database) is a comprehensive online resource that catalogues experimentally verified pathogenicity, virulence, and effector genes from various pathogens. It serves as a critical tool for researchers studying the molecular mechanisms of infectious diseases and the interactions between pathogens and their hosts.
-[[PHI-base]] contains information on pathogenicity, virulence and effector genes from various pathogens. The database is freely available and can be accessed online. It is a valuable resource for researchers studying [[pathogenicity]], [[virulence]], and [[effector genes]], as well as those working in related fields such as [[genomics]], [[proteomics]], and [[bioinformatics]].
+==History==
+PHI-base was established to provide a centralized repository of information on pathogen-host interactions. It was developed to support the scientific community by offering access to curated data that can be used to understand the genetic basis of pathogenicity and host resistance.
-== Content ==
+==Content==
+PHI-base contains detailed information on:
+* Pathogenicity genes: Genes that are essential for a pathogen to cause disease.
+* Virulence genes: Genes that enhance the severity of disease symptoms.
+* Effector genes: Genes that encode proteins or molecules that manipulate host cell processes.
-The content of PHI-base is derived from peer-reviewed literature. Each entry in the database is manually curated and provides detailed information about the gene, including its name, synonyms, functional description, and the pathogen in which it is found. The database also includes information about the host species that the pathogen infects, the disease that it causes, and any known interactions between the gene and host proteins.
+The database includes data from a wide range of pathogens, including bacteria, fungi, oomycetes, and viruses, and their interactions with plant, animal, and human hosts.
-== Applications ==
+==Functionality==
+PHI-base provides several features to facilitate research:
+* '''Search and Browse''': Users can search for specific genes, pathogens, or host species.
+* '''Data Export''': Researchers can download data for further analysis.
+* '''Curation''': The database is regularly updated with new findings from scientific literature.
-PHI-base is used by researchers worldwide to identify potential targets for chemical intervention in the treatment of various diseases. By understanding the structure of essential pathogen genes, researchers can design chemical inhibitors that can control the disease.
+==Applications==
+PHI-base is used in various fields of research, including:
-== See also ==
+* '''Agricultural Science''': Understanding plant-pathogen interactions to develop disease-resistant crops.
+* '''Medical Research''': Identifying potential targets for new antimicrobial drugs.
+* '''Epidemiology''': Studying the spread and control of infectious diseases.
+==Related pages==
 * [[Pathogen]]
-* [[Virulence]]
+* [[Host (biology)]]
-* [[Effector (biology)|Effector genes]]
+* [[Virulence factor]]
-* [[Bioinformatics]]
+* [[Effector (biology)]]
-* [[Genomics]]
+* [[Infectious disease]]
-* [[Proteomics]]
-== References ==
-<references />
-== External links ==
-* [http://www.phi-base.org/ Official website]
 [[Category:Biological databases]]
-[[Category:Genomics]]
+[[Category:Pathogen-host interactions]]
-[[Category:Proteomics]]
-[[Category:Bioinformatics]]
-{{stub}}