PHA-543,613: Difference between revisions

Latest revision as of 03:33, 13 February 2025

PHA-543,613[edit]

PHA-543,613 is a chemical compound that acts as a selective agonist for the _7 nicotinic acetylcholine receptor (_7 nAChR). It is primarily used in scientific research to study the role of this receptor in various physiological and pathological processes.

Mechanism of Action[edit]

PHA-543,613 binds to the _7 nicotinic acetylcholine receptor, which is a type of ligand-gated ion channel found in the central nervous system and other tissues. Activation of this receptor by PHA-543,613 leads to the opening of the ion channel, allowing the flow of calcium and other ions into the cell. This can result in various downstream effects, including modulation of neurotransmitter release and neuroprotection.

Pharmacological Effects[edit]

The activation of _7 nAChRs by PHA-543,613 has been shown to have several potential therapeutic effects, including:

Cognitive Enhancement: Studies suggest that PHA-543,613 may improve cognitive function by enhancing synaptic plasticity and long-term potentiation in the hippocampus.
Neuroprotection: The compound may protect neurons from apoptosis and oxidative stress, which is beneficial in conditions like Alzheimer's disease and Parkinson's disease.
Anti-inflammatory Effects: Activation of _7 nAChRs can modulate the immune response and reduce inflammation, which may be useful in treating autoimmune diseases.

Research Applications[edit]

PHA-543,613 is widely used in preclinical research to explore the therapeutic potential of _7 nAChR agonists. It serves as a tool compound to:

Investigate the role of _7 nAChRs in cognition and memory.
Study the neuroprotective mechanisms in neurodegenerative diseases.
Explore the anti-inflammatory pathways mediated by _7 nAChRs.

Safety and Toxicity[edit]

While PHA-543,613 is a valuable research tool, its safety and toxicity profile in humans is not well-established. Most studies have been conducted in animal models, and further research is needed to determine its potential as a therapeutic agent.

Related Pages[edit]

@@ Line 1: / Line 1: @@
-'''PHA-543,613''' is a [[drug]] that acts as a potent and selective [[agonist]] for the [[alpha7 nicotinic acetylcholine receptor]]. It is used in scientific research and has no current medical or commercial uses.
+== PHA-543,613 ==
-==Pharmacology==
+[[File:PHA-543,613.svg|thumb|right|Chemical structure of PHA-543,613]]
-PHA-543,613 is a full agonist at the alpha7 nicotinic acetylcholine receptor, meaning it can fully activate the receptor while not being subject to regulation by the body's own [[neurotransmitters]]. This makes it useful in research into the function of these receptors, and potential future drug development.
-==Chemistry==
+'''PHA-543,613''' is a chemical compound that acts as a selective agonist for the [[_7 nicotinic acetylcholine receptor]] (_7 nAChR). It is primarily used in scientific research to study the role of this receptor in various physiological and pathological processes.
-PHA-543,613 is a [[quinuclidine]] derivative. Quinuclidine is a nitrogen-containing [[heterocyclic compound]] with the molecular formula C7H13N. The structure of PHA-543,613 includes a quinuclidine ring, which is believed to contribute to its activity at the alpha7 nicotinic acetylcholine receptor.
-==Research==
+== Mechanism of Action ==
-Research into PHA-543,613 has focused on its potential use in the treatment of [[neurodegenerative diseases]] such as [[Alzheimer's disease]] and [[schizophrenia]], where dysfunction of the alpha7 nicotinic acetylcholine receptor is believed to play a role. However, as of now, it is only used in preclinical research and has not been tested in humans.
-==See also==
+PHA-543,613 binds to the _7 nicotinic acetylcholine receptor, which is a type of [[ligand-gated ion channel]] found in the [[central nervous system]] and other tissues. Activation of this receptor by PHA-543,613 leads to the opening of the ion channel, allowing the flow of [[calcium]] and other ions into the cell. This can result in various downstream effects, including modulation of [[neurotransmitter]] release and [[neuroprotection]].
-* [[Alpha7 nicotinic acetylcholine receptor]]
-* [[Agonist]]
-* [[Neurodegenerative diseases]]
-[[Category:Drugs]]
+== Pharmacological Effects ==
-[[Category:Research chemicals]]
+The activation of _7 nAChRs by PHA-543,613 has been shown to have several potential therapeutic effects, including:
+* '''Cognitive Enhancement''': Studies suggest that PHA-543,613 may improve cognitive function by enhancing synaptic plasticity and [[long-term potentiation]] in the [[hippocampus]].
+* '''Neuroprotection''': The compound may protect neurons from [[apoptosis]] and [[oxidative stress]], which is beneficial in conditions like [[Alzheimer's disease]] and [[Parkinson's disease]].
+* '''Anti-inflammatory Effects''': Activation of _7 nAChRs can modulate the [[immune response]] and reduce inflammation, which may be useful in treating [[autoimmune diseases]].
+== Research Applications ==
+PHA-543,613 is widely used in [[preclinical research]] to explore the therapeutic potential of _7 nAChR agonists. It serves as a tool compound to:
+* Investigate the role of _7 nAChRs in [[cognition]] and memory.
+* Study the neuroprotective mechanisms in [[neurodegenerative diseases]].
+* Explore the anti-inflammatory pathways mediated by _7 nAChRs.
+== Safety and Toxicity ==
+While PHA-543,613 is a valuable research tool, its safety and toxicity profile in humans is not well-established. Most studies have been conducted in [[animal models]], and further research is needed to determine its potential as a therapeutic agent.
+== Related Pages ==
+* [[Nicotinic acetylcholine receptor]]
+* [[Neurotransmitter]]
+* [[Cognition]]
+* [[Neuroprotection]]
+[[Category:Pharmacology]]
 [[Category:Neuroscience]]
-{{pharma-stub}}