Trifarotene: Difference between revisions
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== Trifarotene == | |||
[[File:Trifarotene.svg|thumb|right|Chemical structure of Trifarotene]] | |||
Trifarotene is | |||
'''Trifarotene''' is a [[retinoid]] medication primarily used in the treatment of [[acne vulgaris]]. It is notable for its selective action on the [[retinoic acid receptor]] (RAR) gamma, which is the most common RAR found in the skin. This selectivity is believed to contribute to its efficacy and tolerability in treating acne. | |||
== Mechanism of Action == | == Mechanism of Action == | ||
Trifarotene | |||
Trifarotene works by binding to the RAR gamma, which is a type of nuclear receptor. This binding modulates the expression of genes involved in cell differentiation and proliferation. By influencing these processes, trifarotene helps to normalize the shedding of dead skin cells, reduce inflammation, and decrease the formation of comedones, which are the primary lesions in acne. | |||
== Clinical Use == | |||
Trifarotene is available as a topical cream and is applied directly to the skin. It is indicated for the treatment of facial and truncal acne in patients aged 9 years and older. The cream is typically applied once daily in the evening to the affected areas after cleansing. | |||
== Side Effects == | == Side Effects == | ||
== | Common side effects of trifarotene include skin irritation, dryness, and redness at the site of application. These effects are generally mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer to help manage dryness and irritation. | ||
== Advantages == | |||
One of the main advantages of trifarotene over other retinoids is its selective action on RAR gamma, which may result in fewer side effects and better tolerability. Additionally, its efficacy in treating both facial and truncal acne makes it a versatile option for patients with widespread acne. | |||
== Related Pages == | == Related Pages == | ||
* [[Acne vulgaris]] | * [[Acne vulgaris]] | ||
* [[Retinoid]] | * [[Retinoid]] | ||
* [[Retinoic acid receptor]] | * [[Retinoic acid receptor]] | ||
[[Category:Dermatology]] | |||
[[Category:Retinoids]] | [[Category:Retinoids]] | ||
Latest revision as of 03:31, 13 February 2025
Trifarotene[edit]
Trifarotene is a retinoid medication primarily used in the treatment of acne vulgaris. It is notable for its selective action on the retinoic acid receptor (RAR) gamma, which is the most common RAR found in the skin. This selectivity is believed to contribute to its efficacy and tolerability in treating acne.
Mechanism of Action[edit]
Trifarotene works by binding to the RAR gamma, which is a type of nuclear receptor. This binding modulates the expression of genes involved in cell differentiation and proliferation. By influencing these processes, trifarotene helps to normalize the shedding of dead skin cells, reduce inflammation, and decrease the formation of comedones, which are the primary lesions in acne.
Clinical Use[edit]
Trifarotene is available as a topical cream and is applied directly to the skin. It is indicated for the treatment of facial and truncal acne in patients aged 9 years and older. The cream is typically applied once daily in the evening to the affected areas after cleansing.
Side Effects[edit]
Common side effects of trifarotene include skin irritation, dryness, and redness at the site of application. These effects are generally mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer to help manage dryness and irritation.
Advantages[edit]
One of the main advantages of trifarotene over other retinoids is its selective action on RAR gamma, which may result in fewer side effects and better tolerability. Additionally, its efficacy in treating both facial and truncal acne makes it a versatile option for patients with widespread acne.
