Argentina anserina: Difference between revisions

Latest revision as of 19:47, 11 February 2025

A tyrosine kinase inhibitor used in cancer treatment

{{Drugbox | verifiedfields = changed | verifiedrevid = 477002123 | IUPAC_name = N-[[4-(1-[[4-(pyridin-4-yl)butyl]amino]cyclopentyl)oxy]phenyl]-N-methylpyridine-3-carboxamide | image = Apatinib_structure.svg | width = 200 }}

Apatinib, also known as YN968D1, is a small-molecule tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor 2 (VEGFR-2). It is primarily used in the treatment of various types of cancer, including gastric cancer and non-small cell lung cancer.

Mechanism of Action[edit]

Apatinib functions by targeting and inhibiting the activity of VEGFR-2, a receptor that plays a crucial role in angiogenesis, the process by which new blood vessels form from pre-existing vessels. By blocking this receptor, apatinib effectively reduces the blood supply to tumors, thereby inhibiting their growth and proliferation.

Clinical Applications[edit]

Apatinib has been studied extensively in clinical trials for its efficacy in treating advanced gastric cancer, particularly in patients who have not responded to other treatments. It has shown promise in improving progression-free survival and overall survival rates in these patients. Additionally, apatinib is being investigated for its potential use in other cancers, such as breast cancer and colorectal cancer.

Pharmacokinetics[edit]

Apatinib is administered orally and is absorbed into the bloodstream, where it reaches peak plasma concentrations within a few hours. It is metabolized primarily in the liver and excreted through the feces. The drug has a half-life of approximately 9 hours, allowing for once-daily dosing.

Side Effects[edit]

Common side effects of apatinib include hypertension, proteinuria, and hand-foot syndrome. Patients may also experience fatigue, diarrhea, and anorexia. It is important for healthcare providers to monitor patients for these adverse effects and manage them appropriately.

Research and Development[edit]

Ongoing research is exploring the use of apatinib in combination with other chemotherapeutic agents and immunotherapies to enhance its efficacy and broaden its application in cancer treatment. Studies are also investigating biomarkers that may predict patient response to apatinib, allowing for more personalized treatment approaches.

Related pages[edit]

Gallery[edit]

Chemical structure of Apatinib

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-'''Argentina anserina''' is a species of flowering plant in the family [[Rosaceae]], commonly known as '''silverweed''' or '''common silverweed'''. It is native to temperate regions of the Northern Hemisphere, but it has been introduced and naturalized in many other areas worldwide.
+{{Short description|A tyrosine kinase inhibitor used in cancer treatment}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| IUPAC_name = ''N''-[[4-(1-[[4-(pyridin-4-yl)butyl]amino]cyclopentyl)oxy]phenyl]-''N''-methylpyridine-3-carboxamide
+| image = Apatinib_structure.svg
+| width = 200
+}}
-== Description ==
+'''Apatinib''', also known as ''YN968D1'', is a small-molecule [[tyrosine kinase inhibitor]] that selectively inhibits the [[vascular endothelial growth factor receptor 2]] (VEGFR-2). It is primarily used in the treatment of various types of [[cancer]], including [[gastric cancer]] and [[non-small cell lung cancer]].
-[[Argentina anserina]] is a perennial herb that forms a dense mat of foliage. The leaves are pinnate, with 7-15 leaflets that are silvery white on the underside due to a dense covering of small white hairs. The flowers are bright yellow and are produced from late spring to mid-summer.
-== Distribution and habitat ==
+==Mechanism of Action==
-[[Argentina anserina]] is native to temperate regions of the Northern Hemisphere, including Europe, Asia, and North America. It has been introduced to other parts of the world, including South America, Australia, and New Zealand. It typically grows in moist, sandy soils and is often found in coastal areas, along riverbanks, and in other wetland habitats.
+Apatinib functions by targeting and inhibiting the activity of VEGFR-2, a receptor that plays a crucial role in [[angiogenesis]], the process by which new blood vessels form from pre-existing vessels. By blocking this receptor, apatinib effectively reduces the blood supply to tumors, thereby inhibiting their growth and proliferation.
-== Uses ==
+==Clinical Applications==
-[[Argentina anserina]] has been used in traditional medicine for its astringent and anti-inflammatory properties. It has also been used as a food source by various indigenous peoples. The leaves can be eaten raw or cooked, and the roots can be boiled or roasted.
+Apatinib has been studied extensively in clinical trials for its efficacy in treating advanced [[gastric cancer]], particularly in patients who have not responded to other treatments. It has shown promise in improving [[progression-free survival]] and overall survival rates in these patients. Additionally, apatinib is being investigated for its potential use in other cancers, such as [[breast cancer]] and [[colorectal cancer]].
-== Cultivation ==
+==Pharmacokinetics==
-[[Argentina anserina]] is a hardy plant that can tolerate a range of soil types and conditions. It prefers full sun but can tolerate partial shade. It is often used in landscaping for its attractive foliage and bright yellow flowers.
+Apatinib is administered orally and is absorbed into the bloodstream, where it reaches peak plasma concentrations within a few hours. It is metabolized primarily in the liver and excreted through the feces. The drug has a half-life of approximately 9 hours, allowing for once-daily dosing.
-== Conservation ==
+==Side Effects==
-While [[Argentina anserina]] is not currently considered threatened, its habitat is being lost due to human activities such as development and agriculture. Conservation efforts are focused on preserving its natural habitats and preventing further loss of populations.
+Common side effects of apatinib include [[hypertension]], [[proteinuria]], and [[hand-foot syndrome]]. Patients may also experience [[fatigue]], [[diarrhea]], and [[anorexia]]. It is important for healthcare providers to monitor patients for these adverse effects and manage them appropriately.
-== See also ==
+==Research and Development==
-* [[Rosaceae]]
+Ongoing research is exploring the use of apatinib in combination with other [[chemotherapeutic agents]] and [[immunotherapies]] to enhance its efficacy and broaden its application in cancer treatment. Studies are also investigating biomarkers that may predict patient response to apatinib, allowing for more personalized treatment approaches.
-* [[Perennial plant]]
-* [[Traditional medicine]]
-[[Category:Flora of Europe]]
+==Related pages==
-[[Category:Flora of Asia]]
+* [[Tyrosine kinase inhibitor]]
-[[Category:Flora of North America]]
+* [[Vascular endothelial growth factor receptor]]
-[[Category:Rosaceae]]
+* [[Gastric cancer]]
-{{Rosaceae-stub}}
+* [[Angiogenesis]]
+==Gallery==
+<gallery>
+File:Apatinib_structure.svg|Chemical structure of Apatinib
+</gallery>
+[[Category:Antineoplastic drugs]]
+[[Category:Tyrosine kinase inhibitors]]