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Revision as of 04:54, 11 February 2025
PRKCQ (Protein Kinase C Theta) is a protein that in humans is encoded by the PRKCQ gene. This protein is a member of the Protein Kinase C (PKC) family of serine/threonine protein kinases which can be activated by calcium and the second messenger diacylglycerol.
Function
PRKCQ protein is involved in diverse cellular signaling pathways including the B-cell receptor (BCR) signalosome, the Fc epsilon RI-mediated mast cell activation, the T cell receptor (TCR) signaling, and the NF-kappaB signaling pathway. The protein is predominantly expressed in hematopoietic cells.
Clinical significance
Mutations in PRKCQ have been associated with autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis.
Etymology
The term PRKCQ is an abbreviation for Protein Kinase C Theta. The term 'Protein Kinase' refers to a type of enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). 'C' refers to the specific subtype of this enzyme family, and 'Theta' is a further classification within this subtype.
