OR9A2

OR9A2 is a gene that encodes a protein in humans. This protein is part of the olfactory receptor family, a group of proteins that are involved in the detection of smell. The OR9A2 gene is located on chromosome 11.

Function

The olfactory receptor proteins, such as the one encoded by the OR9A2 gene, are located in the cell membranes of olfactory receptor neurons. These neurons are found in a small region at the back of the nose. The olfactory receptors bind to specific odor molecules, triggering a nerve impulse that is sent to the brain. This process allows us to detect and identify a wide range of smells.

Structure

The OR9A2 gene is composed of a single exon and is approximately 1 kilobase in length. The protein it encodes is a member of the G protein-coupled receptor superfamily. This family of proteins has a characteristic structure with seven transmembrane domains.

Clinical significance

Mutations in the OR9A2 gene can lead to a reduced sense of smell, a condition known as anosmia. This can be either congenital (present from birth) or acquired later in life due to injury or illness. Anosmia can have a significant impact on quality of life, as it can affect the ability to taste food and detect dangerous smells such as smoke or gas.

Research

Research into the OR9A2 gene and its associated protein is ongoing. Scientists are interested in understanding more about how the olfactory system works at a molecular level, and how mutations in genes like OR9A2 can affect our sense of smell. This research could potentially lead to new treatments for conditions like anosmia.

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References

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External links

• OR9A2 at NCBI
• OR9A2 at GeneCards
• OR9A2 at UniProt

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor