OR52W1

OR52W1 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in the nose, and is the largest gene family in the human genome. The OR52W1 gene is located on chromosome 11 in humans.

Function

The olfactory receptor proteins, such as the one encoded by the OR52W1 gene, are responsible for detecting odorants in the nasal cavity. These receptors are located on the cilia of the olfactory sensory neurons, which are located in a small area in the upper part of the nasal epithelium. When an odorant binds to an olfactory receptor, it triggers a signal transduction pathway that results in a nerve impulse being sent to the brain.

Structure

The OR52W1 protein is a member of the G protein-coupled receptor family. These receptors have seven transmembrane domains, with the N-terminus located outside the cell and the C-terminus inside the cell. The odorant-binding site is believed to be located in the transmembrane domains.

Clinical significance

While the exact role of the OR52W1 gene in disease is not well understood, it is thought that mutations in this gene could potentially affect the sense of smell. Further research is needed to fully understand the clinical significance of this gene.

See also

• Olfactory receptor
• G protein-coupled receptor
• Signal transduction

References

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