Norelgestromin/ethinylestradiol

Norelgestromin/ethinylestradiol is a combination of two hormones, norelgestromin and ethinylestradiol, used in hormonal contraception. It is marketed under various brand names including Ortho Evra and Xulane.

Etymology

The name "norelgestromin" is derived from "norethindrone", a synthetic progestin, and "gestodene", a third-generation progestin. "Ethinylestradiol" is derived from "estradiol", a naturally occurring estrogen, and "ethinyl", indicating the addition of an ethinyl group.

Pharmacology

Norelgestromin/ethinylestradiol is a transdermal patch that releases the hormones norelgestromin and ethinylestradiol into the bloodstream. Norelgestromin is a progestin, or synthetic progesterone, which works by preventing ovulation and thickening cervical mucus to prevent sperm from reaching the egg. Ethinylestradiol is a synthetic estrogen that works in conjunction with the progestin to prevent ovulation.

Uses

Norelgestromin/ethinylestradiol is used as a method of birth control, to prevent pregnancy. It is also used to treat menstrual disorders, acne, and symptoms of premenstrual syndrome.

Side Effects

Common side effects of norelgestromin/ethinylestradiol include nausea, vomiting, headache, stomach cramping/bloating, breast tenderness, and weight change. Serious side effects include blood clots, stroke, and heart attacks.

See Also

• Hormonal contraception
• Progestin
• Estrogen

References

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