Ets

Ets - oncogene ets was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of e26, an avian leukosis virus. Ets1 encodes 42-52 kd nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the tcra gene. Ets1 also regulates p16(ink4a) gene expression. The human gene is located at 11q23.3.

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