CREB3

CREB3 also known as cAMP responsive element binding protein 3 is a protein that in humans is encoded by the CREB3 gene. This protein is a member of the cAMP responsive element binding protein family and plays a crucial role in various cellular processes.

Function

CREB3 is a transcription factor that is involved in regulating genes during cellular stress response and cellular differentiation. It is activated by endoplasmic reticulum stress and regulates the expression of genes that are involved in the unfolded protein response.

Structure

The CREB3 protein is a type II transmembrane protein that is located in the endoplasmic reticulum. Upon activation, it is cleaved and a part of it translocates to the nucleus where it activates the transcription of target genes.

Clinical significance

Mutations in the CREB3 gene have been associated with various diseases. For example, it has been implicated in osteogenesis imperfecta, a condition that affects bone strength. Additionally, it has been suggested that CREB3 may play a role in cancer development and progression.

See also

• CREB
• Transcription factor
• Endoplasmic reticulum stress
• Unfolded protein response

References

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