UH-232: Difference between revisions

Revision as of 16:11, 9 February 2025

UH-232

UH-232 is a chemical compound that has been studied for its potential effects on the dopamine receptor system. It is a derivative of the compound apomorphine, which is known for its action as a dopamine agonist.

Chemical Structure

The chemical structure of UH-232 is characterized by its unique arrangement of atoms, which can be visualized in the following diagram:

Pharmacology

UH-232 acts primarily as a dopamine receptor antagonist, meaning it binds to dopamine receptors but does not activate them, thereby blocking the action of dopamine. This property makes it of interest in the study of neuropsychiatric disorders where dopamine dysregulation is a factor, such as schizophrenia and bipolar disorder.

Research and Applications

Research into UH-232 has focused on its potential therapeutic applications and its role in modulating dopamine-related pathways. Studies have shown that UH-232 can influence dopaminergic signaling in the brain, which may have implications for the treatment of disorders characterized by excessive dopamine activity.

Related Compounds

UH-232 is related to other compounds such as (+)-AJ76, which also interact with the dopamine system. The structure of (+)-AJ76 is shown below:

Related Pages

References

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-'''UH-232‏‎''' is a [[chemical compound]] that is often used in [[pharmacology]] and [[neuroscience]] research. It is a selective [[antagonist]] for the [[dopamine]] D2 and D3 receptors, which are primarily found in the [[brain]].
+== UH-232 ==
-== History ==
+'''UH-232''' is a chemical compound that has been studied for its potential effects on the [[dopamine receptor]] system. It is a derivative of the compound [[apomorphine]], which is known for its action as a [[dopamine agonist]].
-UH-232 was first synthesized in the late 20th century as part of a series of compounds designed to study the effects of dopamine in the brain. It was developed by researchers at the [[University of Houston]], which is how it got its name.
+== Chemical Structure ==
+The chemical structure of UH-232 is characterized by its unique arrangement of atoms, which can be visualized in the following diagram:
+[[File:UH-232_Structure.svg|thumb|right|Chemical structure of UH-232]]
 == Pharmacology ==
-UH-232 works by binding to the D2 and D3 dopamine receptors in the brain, preventing dopamine from activating these receptors. This can help to reduce the effects of conditions that are caused by excessive dopamine activity, such as [[schizophrenia]] and [[Parkinson's disease]].
+UH-232 acts primarily as a [[dopamine receptor antagonist]], meaning it binds to dopamine receptors but does not activate them, thereby blocking the action of dopamine. This property makes it of interest in the study of [[neuropsychiatric disorders]] where dopamine dysregulation is a factor, such as [[schizophrenia]] and [[bipolar disorder]].
-== Uses ==
+== Research and Applications ==
-In research, UH-232 is often used as a tool to study the role of dopamine in the brain. It can be used in animal models to induce symptoms similar to those seen in schizophrenia and Parkinson's disease, allowing researchers to study these conditions in a controlled environment.
+Research into UH-232 has focused on its potential therapeutic applications and its role in modulating dopamine-related pathways. Studies have shown that UH-232 can influence [[dopaminergic signaling]] in the brain, which may have implications for the treatment of disorders characterized by excessive dopamine activity.
-In medicine, UH-232 has potential as a treatment for conditions that are caused by excessive dopamine activity. However, it is not currently approved for use in humans.
+== Related Compounds ==
-== Side Effects ==
+UH-232 is related to other compounds such as [[(+)-AJ76]], which also interact with the dopamine system. The structure of (+)-AJ76 is shown below:
-As with any drug, UH-232 can have side effects. These can include [[nausea]], [[vomiting]], and [[dizziness]]. In animal studies, it has also been shown to cause changes in behavior, such as increased aggression and decreased social interaction.
+[[File:(+)-AJ76_structure.png|thumb|right|Chemical structure of (+)-AJ76]]
-== See Also ==
+== Related Pages ==
-* [[Dopamine]]
 * [[Dopamine receptor]]
-* [[Schizophrenia]]
+* [[Dopamine antagonist]]
-* [[Parkinson's disease]]
+* [[Neurotransmitter]]
 == References ==
-<references />
+{{Reflist}}
+[[Category:Dopamine antagonists]]
 [[Category:Chemical compounds]]
-[[Category:Pharmacology]]
-[[Category:Neuroscience]]
-{{Chem-stub}}
-{{Pharma-stub}}