Unilateral palmoplantar verrucous nevus: Difference between revisions

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Unilateral palmoplantar verrucous nevus

Unilateral palmoplantar verrucous nevus is a rare dermatological condition characterized by the presence of wart-like lesions on the palms and soles, typically affecting only one side of the body. This condition is a type of epidermal nevus, which is a benign growth of the skin.

Presentation

The condition manifests as thickened, verrucous (wart-like) plaques that are confined to the palm and/or sole of one side of the body. These lesions are usually present at birth or develop in early childhood. The affected skin may appear hyperkeratotic and can sometimes be painful, especially when pressure is applied, such as during walking.

Pathophysiology

Unilateral palmoplantar verrucous nevus is thought to result from a postzygotic somatic mutation, leading to mosaicism. This means that the genetic mutation is present in only a portion of the body's cells, which explains the localized nature of the lesions. The exact genetic mutations involved are not fully understood, but they are believed to affect the keratinocytes, the predominant cell type in the epidermis.

Diagnosis

Diagnosis is primarily clinical, based on the characteristic appearance and distribution of the lesions. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions such as verruca vulgaris (common warts) or palmoplantar keratoderma. Histological examination typically shows hyperkeratosis, acanthosis, and papillomatosis.

Treatment

Treatment options are limited and primarily aimed at managing symptoms. Topical keratolytics, such as salicylic acid, can be used to reduce hyperkeratosis. In some cases, surgical removal or laser therapy may be considered, although recurrence is common. Regular follow-up with a dermatologist is recommended to monitor the condition.

Prognosis

The condition is benign and does not typically lead to serious health issues. However, the lesions can be cosmetically concerning and may cause discomfort. The prognosis is generally good, with management focused on symptom relief.

Related pages

References

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-'''Unilateral Palmoplantar Verrucous Nevus''' (UPVN) is a rare [[skin condition]] characterized by the development of verrucous (wart-like) [[nevus|nevi]] (moles) predominantly on one side of the body, affecting the palms of the hands and/or the soles of the feet. This condition is a type of [[epidermal nevus]], which is a broader category of skin lesions that are present at birth or develop early in life and consist of an overgrowth of cells found in the [[epidermis]] (the outer layer of the skin).
+== Unilateral palmoplantar verrucous nevus ==
-==Etiology and Pathogenesis==
+'''Unilateral palmoplantar verrucous nevus''' is a rare dermatological condition characterized by the presence of wart-like lesions on the palms and soles, typically affecting only one side of the body. This condition is a type of [[epidermal nevus]], which is a benign growth of the skin.
-The exact cause of Unilateral Palmoplantar Verrucous Nevus is not well understood. It is believed to result from postzygotic somatic mutations that occur during embryonic development, leading to mosaicism. These mutations affect the proliferation and differentiation of keratinocytes, the predominant cell type in the epidermis. Unlike hereditary conditions, UPVN does not follow a genetic inheritance pattern and occurs sporadically.
-==Clinical Features==
+== Presentation ==
-Patients with UPVN present with well-demarcated, thickened, verrucous plaques that are limited to the palms and soles. The lesions are typically unilateral, affecting either the left or the right side of the body. The condition is usually present at birth or manifests in early childhood. Although the lesions are benign, they can cause discomfort or pain, especially when located on weight-bearing areas of the feet, leading to difficulties in walking or performing manual tasks.
-==Diagnosis==
+The condition manifests as thickened, verrucous (wart-like) plaques that are confined to the palm and/or sole of one side of the body. These lesions are usually present at birth or develop in early childhood. The affected skin may appear hyperkeratotic and can sometimes be painful, especially when pressure is applied, such as during walking.
-Diagnosis of Unilateral Palmoplantar Verrucous Nevus is primarily clinical, based on the characteristic appearance and distribution of the lesions. Dermoscopy, a non-invasive imaging technique, can aid in the diagnosis by revealing specific patterns associated with verrucous nevi. In uncertain cases, a [[biopsy]] may be performed to exclude other conditions and to confirm the diagnosis histologically. Histopathological examination typically shows hyperkeratosis, acanthosis, and papillomatosis, which are indicative of verrucous nevi.
-==Treatment==
+== Pathophysiology ==
-Treatment of UPVN is challenging and focuses on relieving symptoms and improving the cosmetic appearance of the lesions. Options include topical treatments, such as keratolytics (agents that soften and break down the keratin in the skin), and surgical interventions like laser therapy, cryotherapy, or excision. However, these treatments may not be completely effective and carry the risk of scarring or recurrence of the lesions.
-==Prognosis==
+Unilateral palmoplantar verrucous nevus is thought to result from a postzygotic somatic mutation, leading to mosaicism. This means that the genetic mutation is present in only a portion of the body's cells, which explains the localized nature of the lesions. The exact genetic mutations involved are not fully understood, but they are believed to affect the [[keratinocyte]]s, the predominant cell type in the epidermis.
-The prognosis for individuals with Unilateral Palmoplantar Verrucous Nevus is generally good, as the condition is benign and does not affect overall health. However, the cosmetic and functional implications of the lesions can significantly impact the quality of life. Regular follow-up with a dermatologist is recommended to monitor the lesions and manage any complications.
+== Diagnosis ==
+Diagnosis is primarily clinical, based on the characteristic appearance and distribution of the lesions. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions such as [[verruca vulgaris]] (common warts) or [[palmoplantar keratoderma]]. Histological examination typically shows hyperkeratosis, acanthosis, and papillomatosis.
+== Treatment ==
+Treatment options are limited and primarily aimed at managing symptoms. Topical keratolytics, such as salicylic acid, can be used to reduce hyperkeratosis. In some cases, surgical removal or laser therapy may be considered, although recurrence is common. Regular follow-up with a dermatologist is recommended to monitor the condition.
+== Prognosis ==
+The condition is benign and does not typically lead to serious health issues. However, the lesions can be cosmetically concerning and may cause discomfort. The prognosis is generally good, with management focused on symptom relief.
+== Related pages ==
+* [[Epidermal nevus]]
+* [[Verruca vulgaris]]
+* [[Palmoplantar keratoderma]]
+== References ==
+{{Reflist}}
 [[Category:Dermatology]]
-[[Category:Skin conditions]]
+[[Category:Congenital disorders]]
-{{medicine-stub}}