UniProt: Difference between revisions

Revision as of 11:57, 9 February 2025

UniProt

File:Uniprot-logo.img.svg

Logo of UniProt

UniProt is a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. The UniProt databases are maintained by the UniProt Consortium, which includes the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR).

History

The UniProt project was initiated in December 2002 as a merger of three existing protein databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to create a single, comprehensive resource that would provide a more complete and accurate picture of protein sequences and their functions. The first release of UniProt was in 2003.

Components

UniProt consists of several components:

UniProtKB (UniProt Knowledgebase): This is the central database of protein sequences and functional information. It is divided into two sections:

 * Swiss-Prot: A manually annotated and reviewed section of UniProtKB.
 * TrEMBL: A computer-annotated section of UniProtKB, which is not reviewed.

UniParc (UniProt Archive): A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.

UniRef (UniProt Reference Clusters): Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.

Features

UniProt provides a wide range of features, including:

Detailed annotation of protein sequences, including information on function, domain structure, post-translational modifications, variants, and more.
Cross-references to other databases, providing a network of biological information.
Tools for sequence analysis and retrieval.
Regular updates to ensure the most current data is available.

Access and Use

UniProt is freely accessible to the public and can be accessed through its website. Users can search for proteins by name, function, or sequence, and download data in various formats. The database is widely used by researchers in the fields of bioinformatics, molecular biology, and genomics.

Related pages

References

External links

Official UniProt website

@@ Line 1: / Line 1: @@
-'''UniProt''' is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
+== UniProt ==
-== Overview ==
+[[File:Uniprot-logo.img.svg|thumb|Logo of UniProt]]
-The UniProt consortium comprises the [[European Bioinformatics Institute]], the [[Swiss Institute of Bioinformatics]] and the [[Protein Information Resource]]. It is a collaboration between these institutes that aims to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.
-== Content ==
+'''UniProt''' is a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. The UniProt databases are maintained by the [[UniProt Consortium]], which includes the [[European Bioinformatics Institute]] (EBI), the [[Swiss Institute of Bioinformatics]] (SIB), and the [[Protein Information Resource]] (PIR).
-UniProt provides four core databases, each optimized for different uses. The databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), the UniProt Archive (UniParc), and the UniProt Metagenomic and Environmental Sequences (UniMES) database.
-=== UniProt Knowledgebase ===
+== History ==
-The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. It consists of two sections: UniProtKB/Swiss-Prot, which is manually annotated and reviewed, and UniProtKB/TrEMBL, which is automatically annotated and not reviewed.
+The UniProt project was initiated in December 2002 as a merger of three existing protein databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to create a single, comprehensive resource that would provide a more complete and accurate picture of protein sequences and their functions. The first release of UniProt was in 2003.
-=== UniProt Reference Clusters ===
+== Components ==
-The UniProt Reference Clusters (UniRef) provide clustered sets of sequences from the UniProt Knowledgebase (including isoforms) and selected UniParc records, in order to obtain complete coverage of the sequence space at several resolutions.
+UniProt consists of several components:
-=== UniProt Archive ===
+* '''[[UniProtKB]] (UniProt Knowledgebase)''': This is the central database of protein sequences and functional information. It is divided into two sections:
-The UniProt Archive (UniParc) is a comprehensive and accurate repository of protein sequences, which are sourced from many different databases.
+  * '''[[Swiss-Prot]]''': A manually annotated and reviewed section of UniProtKB.
+  * '''[[TrEMBL]]''': A computer-annotated section of UniProtKB, which is not reviewed.
-=== UniProt Metagenomic and Environmental Sequences ===
+* '''[[UniParc]] (UniProt Archive)''': A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.
-The UniProt Metagenomic and Environmental Sequences (UniMES) database is a repository specifically developed for the representation of metagenomic and environmental data.
-== See also ==
+* '''[[UniRef]] (UniProt Reference Clusters)''': Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.
-* [[Protein structure]]
-* [[Protein–protein interaction]]
+== Features ==
+UniProt provides a wide range of features, including:
+* Detailed [[annotation]] of protein sequences, including information on function, domain structure, post-translational modifications, variants, and more.
+* Cross-references to other databases, providing a network of biological information.
+* Tools for sequence analysis and retrieval.
+* Regular updates to ensure the most current data is available.
+== Access and Use ==
+UniProt is freely accessible to the public and can be accessed through its website. Users can search for proteins by name, function, or sequence, and download data in various formats. The database is widely used by researchers in the fields of [[bioinformatics]], [[molecular biology]], and [[genomics]].
+== Related pages ==
 * [[Protein Data Bank]]
-* [[Protein subcellular localization prediction]]
+* [[GenBank]]
+* [[Ensembl]]
 == References ==
-<references />
+{{Reflist}}
 == External links ==
-* [http://www.uniprot.org/ Official website]
+* [https://www.uniprot.org/ Official UniProt website]
-[[Category:Protein databases]]
 [[Category:Biological databases]]
-[[Category:Science and technology in Europe]]
+[[Category:Bioinformatics]]
-{{stub}}
+[[Category:Protein structure]]