UniGene: Difference between revisions

Revision as of 11:55, 9 February 2025

UniGene

UniGene logo

UniGene is a system for automatically partitioning GenBank sequences into a non-redundant set of gene-oriented clusters. Each UniGene cluster contains sequences that represent a unique gene, as well as related information such as the tissue types in which the gene has been expressed and map location.

History

UniGene was developed by the National Center for Biotechnology Information (NCBI) as a tool to organize and simplify the study of gene expression. It was first introduced in the late 1990s and has since become a valuable resource for researchers in the field of genomics.

Functionality

UniGene provides a comprehensive view of the transcriptome by clustering mRNA sequences from GenBank, dbEST, and RefSeq into unique gene clusters. Each cluster is assigned a unique identifier and includes sequences from different sources that are believed to represent the same gene. This allows researchers to study gene expression patterns across different tissues and developmental stages.

Applications

UniGene is widely used in bioinformatics and genomics research. It helps in identifying novel genes, studying gene expression, and understanding the genetic basis of diseases. Researchers use UniGene to find expressed sequence tags (ESTs) that are associated with specific genes, which can be useful in gene discovery and functional genomics.

Related pages

References

Schuler, G. D. (1997). "Pieces of the puzzle: Expressed sequence tags and the catalog of human genes." Science, 274(5287), 540-546.
Wheeler, D. L., et al. (2000). "Database resources of the National Center for Biotechnology Information." Nucleic Acids Research, 28(1), 10-14.

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-'''UniGene''' is a database that is maintained by the [[National Center for Biotechnology Information]] (NCBI). It provides an organized view of the [[transcriptome]], and for each known gene, it presents the sequences that represent the gene's transcriptional landscape.
+== UniGene ==
-== Overview ==
+[[File:Unigene_banner.jpg|thumb|right|UniGene logo]]
-The UniGene database is a system for partitioning [[transcript sequences]] into a non-redundant set of gene-oriented clusters. Each UniGene cluster contains sequences that represent a unique gene, as well as related information such as the [[tissue types]] in which the gene has been expressed and map location.
+'''UniGene''' is a system for automatically partitioning [[GenBank]] sequences into a non-redundant set of gene-oriented clusters. Each UniGene cluster contains sequences that represent a unique gene, as well as related information such as the tissue types in which the gene has been expressed and map location.
-== Construction ==
+== History ==
-The UniGene database is constructed by partitioning GenBank sequences into a non-redundant set of gene-oriented clusters. Each UniGene cluster contains sequences that represent a unique gene. The process of creating a UniGene cluster involves several steps:
+UniGene was developed by the [[National Center for Biotechnology Information]] (NCBI) as a tool to organize and simplify the study of gene expression. It was first introduced in the late 1990s and has since become a valuable resource for researchers in the field of [[genomics]].
-# Sequences are partitioned into clusters based on their overlap.
+== Functionality ==
-# Each cluster is then analyzed to identify the most likely representative sequence.
-# The representative sequence is then used to search the rest of the database to find other sequences that may belong to the same gene.
+UniGene provides a comprehensive view of the transcriptome by clustering [[mRNA]] sequences from [[GenBank]], [[dbEST]], and [[RefSeq]] into unique gene clusters. Each cluster is assigned a unique identifier and includes sequences from different sources that are believed to represent the same gene. This allows researchers to study gene expression patterns across different tissues and developmental stages.
 == Applications ==
-UniGene is a valuable resource for many areas of [[genomic research]]. These include:
+UniGene is widely used in [[bioinformatics]] and [[genomics]] research. It helps in identifying novel genes, studying gene expression, and understanding the genetic basis of diseases. Researchers use UniGene to find [[expressed sequence tags]] (ESTs) that are associated with specific genes, which can be useful in [[gene discovery]] and [[functional genomics]].
-# [[Gene discovery]] and [[annotation]]
+== Related pages ==
-# [[Gene expression]] studies
-# [[Comparative genomics]]
-# [[Molecular evolution]] studies
-# [[Disease research]]
-== See also ==
+* [[GenBank]]
+* [[Expressed sequence tag]]
 * [[National Center for Biotechnology Information]]
-* [[GenBank]]
-* [[Transcriptome]]
 * [[Gene expression]]
 == References ==
-{{reflist}}
+* Schuler, G. D. (1997). "Pieces of the puzzle: Expressed sequence tags and the catalog of human genes." Science, 274(5287), 540-546.
+* Wheeler, D. L., et al. (2000). "Database resources of the National Center for Biotechnology Information." Nucleic Acids Research, 28(1), 10-14.
+[[Category:Bioinformatics databases]]
 [[Category:Genomics]]
-[[Category:Bioinformatics databases]]
-[[Category:National Institutes of Health]]
-[[Category:Biological databases]]
-{{biology-stub}}
-{{medicine-stub}}