HOXC12: Difference between revisions

HOXC12
Symbol	HOXC12
HGNC ID	5107
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	12q13.13
Locus supplementary data	–

Latest revision as of 20:46, 30 December 2024

HOXC12 is a gene that encodes a member of the homeobox family of transcription factors. These proteins play a crucial role in the regulation of developmental processes and cell differentiation. The HOXC12 gene is part of the HOXC gene cluster, which is located on chromosome 12 in humans.

Function[edit]

The HOXC12 protein is involved in the regulation of gene expression during embryonic development. It is particularly important in the development of the nervous system and limb formation. Like other homeobox genes, HOXC12 contains a homeodomain, which is a DNA-binding domain that allows the protein to bind to specific DNA sequences and regulate the transcription of target genes.

Clinical Significance[edit]

Mutations or dysregulation of HOXC12 and other homeobox genes can lead to developmental disorders and have been implicated in certain types of cancer. Research is ongoing to better understand the specific roles of HOXC12 in these processes and its potential as a target for therapeutic intervention.

References[edit]

External Links[edit]

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-'''HOXC12''' is a gene that belongs to the [[homeobox]] family of genes. The [[protein]] encoded by this gene is a [[transcription factor]] that plays a crucial role in the development and growth of various tissues and organs in the body.
+{{Infobox gene
+| name = HOXC12
+| symbol = HOXC12
+| HGNCid = 5107
+| chromosome = 12
+| arm = q
+| band = 13.13
+}}
+'''HOXC12''' is a [[gene]] that encodes a member of the [[homeobox]] family of [[transcription factors]]. These proteins play a crucial role in the regulation of [[developmental processes]] and [[cell differentiation]]. The HOXC12 gene is part of the [[HOXC gene cluster]], which is located on [[chromosome 12]] in humans.
 == Function ==
-The HOXC12 gene is part of the [[HOX gene]] family, a group of genes that are essential for the proper development of the body. These genes are responsible for determining the basic structure of an organism, including the formation of the body's major axes and the positioning of its various parts. The HOXC12 gene, in particular, is involved in the development of the [[limbs]] and the [[nervous system]].
+The HOXC12 protein is involved in the regulation of [[gene expression]] during [[embryonic development]]. It is particularly important in the development of the [[nervous system]] and [[limb formation]]. Like other homeobox genes, HOXC12 contains a [[homeodomain]], which is a DNA-binding domain that allows the protein to bind to specific [[DNA sequences]] and regulate the transcription of target genes.
-== Structure ==
-The HOXC12 gene is located on [[chromosome 12]], specifically on the long (q) arm at position 13. The gene spans approximately 3,000 base pairs and consists of two exons. The encoded protein is 284 amino acids long.
 == Clinical Significance ==
-Mutations in the HOXC12 gene have been associated with several medical conditions. For instance, alterations in this gene have been linked to [[congenital limb deformities]] and [[neurological disorders]]. However, more research is needed to fully understand the role of HOXC12 in these conditions.
+Mutations or dysregulation of HOXC12 and other homeobox genes can lead to [[developmental disorders]] and have been implicated in certain types of [[cancer]]. Research is ongoing to better understand the specific roles of HOXC12 in these processes and its potential as a target for therapeutic intervention.
-== Research ==
-Current research is focused on understanding the precise role of HOXC12 in development and disease. This includes studying the gene's function in animal models, as well as investigating its potential as a therapeutic target in conditions such as [[cancer]].
-[[File:HOXC12 gene location on human chromosome 12.png|thumb|right|300px|Location of the HOXC12 gene on human chromosome 12.]]
 == See Also ==
 * [[Homeobox]]
-* [[HOX gene]]
 * [[Transcription factor]]
-* [[Chromosome 12]]
+* [[Gene expression]]
+* [[Embryonic development]]
 == References ==
-<references />
+{{Reflist}}
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/HOXC12 HOXC12 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=HOXC12 HOXC12 Gene - GeneCards]
-[[Category:Genes]]
+[[Category:Genes on human chromosome 12]]
-[[Category:Human proteins]]
 [[Category:Transcription factors]]
-{{medicine-stub}}
+[[Category:Developmental biology]]