IRX2: Difference between revisions

IRX2
Symbol	IRX2
HGNC ID	6119
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	5p15.33
Locus supplementary data	–

Latest revision as of 20:34, 30 December 2024

IRX2 is a member of the Iroquois homeobox gene family, which plays a crucial role in the development of various tissues and organs in the body. The IRX2 gene is located on chromosome 5 and is part of a cluster of Iroquois genes that are involved in embryonic development.

Function[edit]

The IRX2 gene encodes a transcription factor that is involved in the regulation of gene expression during developmental processes. It is particularly important in the development of the nervous system, heart, and limbs. The protein product of the IRX2 gene binds to specific DNA sequences, thereby controlling the transcription of target genes that are essential for proper organogenesis.

Clinical Significance[edit]

Mutations or dysregulation of the IRX2 gene have been associated with various congenital disorders. Research suggests that alterations in IRX2 expression may contribute to developmental abnormalities, although the exact mechanisms remain under investigation. Understanding the role of IRX2 in development could provide insights into the pathogenesis of these conditions and potential therapeutic targets.

Research[edit]

Studies on the IRX2 gene continue to explore its function in normal and pathological conditions. Animal models, such as mouse models, are often used to study the effects of IRX2 gene disruption. These studies help elucidate the gene's role in developmental biology and its potential involvement in disease states.

References[edit]

External Links[edit]

@@ Line 1: / Line 1: @@
-'''IRX2''' is a gene that encodes a member of the Iroquois homeobox gene family. Members of this family are involved in pattern formation and cell differentiation during embryogenesis. The encoded protein has been associated with a variety of biological processes, including organogenesis, and may play a role in cancer development.
-== Function ==
+{{Infobox gene
+| name = IRX2
+| symbol = IRX2
+| HGNCid = 6119
+| chromosome = 5
+| arm = p
+| band = 15.33
+}}
-The [[IRX2]] gene is part of the [[Iroquois homeobox]] gene family, which plays a crucial role in the early stages of [[embryogenesis]]. This gene family is involved in the regulation of [[pattern formation]] and [[cell differentiation]], which are essential processes in the development of an organism.
+'''IRX2''' is a member of the [[Iroquois homeobox gene family]], which plays a crucial role in the development of various tissues and organs in the body. The IRX2 gene is located on [[chromosome 5]] and is part of a cluster of Iroquois genes that are involved in [[embryonic development]].
-The protein encoded by the IRX2 gene is a [[transcription factor]], a type of protein that controls the rate of transcription of genetic information from [[DNA]] to [[messenger RNA]]. This protein has been found to regulate the expression of several genes involved in organogenesis, the process by which the internal organs of an organism are formed.
+== Function ==
+The IRX2 gene encodes a transcription factor that is involved in the regulation of [[gene expression]] during [[developmental processes]]. It is particularly important in the development of the [[nervous system]], [[heart]], and [[limbs]]. The protein product of the IRX2 gene binds to specific DNA sequences, thereby controlling the transcription of target genes that are essential for proper [[organogenesis]].
-== Clinical significance ==
-Alterations in the expression of the IRX2 gene have been associated with a variety of diseases. For example, overexpression of IRX2 has been observed in several types of cancer, including [[breast cancer]], [[gastric cancer]], and [[head and neck squamous cell carcinoma]]. This overexpression has been linked to increased cell proliferation and invasion, suggesting that IRX2 may play a role in cancer development.
-In addition, mutations in the IRX2 gene have been identified in individuals with [[congenital heart disease]], indicating that this gene may also be involved in heart development.
+== Clinical Significance ==
+Mutations or dysregulation of the IRX2 gene have been associated with various [[congenital disorders]]. Research suggests that alterations in IRX2 expression may contribute to developmental abnormalities, although the exact mechanisms remain under investigation. Understanding the role of IRX2 in development could provide insights into the pathogenesis of these conditions and potential therapeutic targets.
 == Research ==
+Studies on the IRX2 gene continue to explore its function in normal and pathological conditions. Animal models, such as [[mouse models]], are often used to study the effects of IRX2 gene disruption. These studies help elucidate the gene's role in [[developmental biology]] and its potential involvement in [[disease states]].
-Research on the IRX2 gene is ongoing, with scientists seeking to better understand its function and its role in disease development. This research may lead to the development of new therapeutic strategies for diseases associated with alterations in the expression or function of this gene.
+== See Also ==
+* [[Iroquois homeobox gene family]]
-[[File:IRX2 gene location on human chromosome 5.png|thumb|right|300px|Location of the IRX2 gene on human chromosome 5.]]
-== See also ==
-* [[Iroquois homeobox]]
 * [[Transcription factor]]
-* [[Organogenesis]]
+* [[Embryonic development]]
-* [[Cancer]]
-* [[Congenital heart disease]]
 == References ==
+<references/>
-{{Reflist}}
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/IRX2 IRX2 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=IRX2 IRX2 Gene - GeneCards]
-[[Category:Genes]]
+[[Category:Genes on human chromosome 5]]
 [[Category:Transcription factors]]
 [[Category:Developmental biology]]
-[[Category:Oncology]]
-[[Category:Cardiology]]
-{{Genes on human chromosome 5}}
-{{medicine-stub}}