NFATC3: Difference between revisions
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'''NFATC3''' | {{Infobox gene | ||
| name = NFATC3 | |||
| symbol = NFATC3 | |||
| HGNCid = 7775 | |||
| OMIM = 600489 | |||
| EntrezGene = 4775 | |||
| RefSeq = NM_173091 | |||
| UniProt = Q12968 | |||
| chromosome = 16 | |||
| arm = q | |||
| band = 22 | |||
}} | |||
'''NFATC3''' (Nuclear Factor of Activated T-Cells, Cytoplasmic 3) is a [[protein]] that in humans is encoded by the '''NFATC3''' [[gene]]. | |||
== Function == | == Function == | ||
NFATC3 is a | NFATC3 is a member of the [[nuclear factor of activated T-cells]] (NFAT) family of transcription factors. These transcription factors are involved in the regulation of [[gene expression]] in response to [[calcium]] signaling. NFAT proteins are critical for the development and function of the [[immune system]], particularly in the activation of [[T-cells]]. | ||
== Structure == | == Structure == | ||
The NFATC3 protein | The NFATC3 protein contains several domains that are important for its function, including a [[Rel homology domain]] (RHD) that is responsible for [[DNA binding]] and a [[transactivation domain]] that interacts with other proteins to regulate transcription. | ||
== Clinical Significance == | == Clinical Significance == | ||
Mutations or dysregulation of NFATC3 have been implicated in various [[diseases]], including [[autoimmune disorders]] and [[cancer]]. Research is ongoing to better understand the role of NFATC3 in these conditions and to develop potential therapeutic strategies. | |||
== | == Interactions == | ||
NFATC3 interacts with several other proteins to exert its effects on gene expression. It can form complexes with other NFAT family members, as well as with [[AP-1]] transcription factors, to regulate the expression of target genes. | |||
[[ | |||
== See Also == | == See Also == | ||
* [[ | * [[NFATC1]] | ||
* [[ | * [[NFATC2]] | ||
* [[NFATC4]] | |||
* [[Transcription factor]] | |||
* [[T-cell receptor]] | * [[T-cell receptor]] | ||
== References == | == References == | ||
{{Reflist}} | |||
== External Links == | |||
* [https://www.ncbi.nlm.nih.gov/gene/4775 NFATC3 Gene - NCBI] | |||
* [https://www.uniprot.org/uniprot/Q12968 NFATC3 Protein - UniProt] | |||
[[Category: | [[Category:Transcription factors]] | ||
[[Category: | [[Category:Human proteins]] | ||
[[Category: | [[Category:Genes on human chromosome 16]] | ||
Latest revision as of 20:32, 30 December 2024
| Symbol | NFATC3 |
|---|---|
| HGNC ID | 7775 |
| Alternative symbols | – |
| Entrez Gene | 4775 |
| OMIM | 600489 |
| RefSeq | NM_173091 |
| UniProt | Q12968 |
| Chromosome | 16q22 |
| Locus supplementary data | – |
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic 3) is a protein that in humans is encoded by the NFATC3 gene.
Function[edit]
NFATC3 is a member of the nuclear factor of activated T-cells (NFAT) family of transcription factors. These transcription factors are involved in the regulation of gene expression in response to calcium signaling. NFAT proteins are critical for the development and function of the immune system, particularly in the activation of T-cells.
Structure[edit]
The NFATC3 protein contains several domains that are important for its function, including a Rel homology domain (RHD) that is responsible for DNA binding and a transactivation domain that interacts with other proteins to regulate transcription.
Clinical Significance[edit]
Mutations or dysregulation of NFATC3 have been implicated in various diseases, including autoimmune disorders and cancer. Research is ongoing to better understand the role of NFATC3 in these conditions and to develop potential therapeutic strategies.
Interactions[edit]
NFATC3 interacts with several other proteins to exert its effects on gene expression. It can form complexes with other NFAT family members, as well as with AP-1 transcription factors, to regulate the expression of target genes.
See Also[edit]
References[edit]
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