S1PR4: Difference between revisions
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'''S1PR4''' | = S1PR4 = | ||
'''S1PR4''' (Sphingosine-1-phosphate receptor 4) is a [[G protein-coupled receptor]] that binds the lipid signaling molecule [[sphingosine-1-phosphate]] (S1P). This receptor is part of the [[sphingosine-1-phosphate receptor]] family, which plays a crucial role in the regulation of various physiological processes, including [[immune system]] function and [[cardiovascular system|cardiovascular]] development. | |||
== Function == | == Function == | ||
S1PR4 is | S1PR4 is primarily expressed in [[lymphoid tissue]] and is involved in the modulation of [[immune cell]] trafficking and function. It is known to influence the behavior of [[T cells]], [[B cells]], and [[natural killer cells]]. The receptor's activity is mediated by its interaction with intracellular [[G proteins]], which transduce signals to downstream effectors, influencing cell migration, proliferation, and survival. | ||
== Clinical | == Clinical Significance == | ||
Alterations in | Alterations in S1PR4 signaling have been implicated in various [[disease]] states, including [[autoimmune disorders]] and [[cancer]]. The receptor is a potential target for therapeutic intervention in conditions where immune cell regulation is disrupted. | ||
== Research == | == Research == | ||
Recent studies have focused on the role of S1PR4 in [[inflammatory diseases]] and its potential as a biomarker for disease progression. The development of selective S1PR4 agonists and antagonists is an area of active research, aiming to modulate immune responses in a controlled manner. | |||
== See Also == | |||
== See | |||
* [[Sphingosine-1-phosphate receptor]] | * [[Sphingosine-1-phosphate receptor]] | ||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[ | * [[Immune system]] | ||
== References == | == References == | ||
<references /> | <references/> | ||
== External Links == | |||
* [https://www.wikimd.com/wiki/S1PR4 S1PR4 on WikiMD] | |||
{{ | {{Receptor-stub}} | ||
{{ | {{GPCR}} | ||
[[Category:Receptors]] | |||
[[Category:Immune system]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
Latest revision as of 20:28, 30 December 2024
S1PR4[edit]
S1PR4 (Sphingosine-1-phosphate receptor 4) is a G protein-coupled receptor that binds the lipid signaling molecule sphingosine-1-phosphate (S1P). This receptor is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in the regulation of various physiological processes, including immune system function and cardiovascular development.
Function[edit]
S1PR4 is primarily expressed in lymphoid tissue and is involved in the modulation of immune cell trafficking and function. It is known to influence the behavior of T cells, B cells, and natural killer cells. The receptor's activity is mediated by its interaction with intracellular G proteins, which transduce signals to downstream effectors, influencing cell migration, proliferation, and survival.
Clinical Significance[edit]
Alterations in S1PR4 signaling have been implicated in various disease states, including autoimmune disorders and cancer. The receptor is a potential target for therapeutic intervention in conditions where immune cell regulation is disrupted.
Research[edit]
Recent studies have focused on the role of S1PR4 in inflammatory diseases and its potential as a biomarker for disease progression. The development of selective S1PR4 agonists and antagonists is an area of active research, aiming to modulate immune responses in a controlled manner.
See Also[edit]
References[edit]
<references/>
External Links[edit]
