OR2D2: Difference between revisions

OR2D2
Symbol	OR2D2
HGNC ID	8181
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	6q23
Locus supplementary data	–

Latest revision as of 20:28, 30 December 2024

OR2D2 is a gene that encodes a member of the olfactory receptor family of proteins. These proteins are involved in the detection of odor molecules and are part of the G protein-coupled receptor (GPCR) superfamily.

Function[edit]

Olfactory receptors, such as OR2D2, are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor proteins share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors, which allows them to interact with odorant molecules in the olfactory epithelium and initiate a neuronal response that triggers the perception of a smell.

Gene Family[edit]

The olfactory receptor gene family is the largest in the human genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. OR2D2 is part of the olfactory receptor family 2, subfamily D, member 2.

Location[edit]

The OR2D2 gene is located on the long arm (q) of chromosome 6 at position 23. This location is significant for the study of genetic linkage and association with various traits and conditions.

Clinical Significance[edit]

While the primary function of OR2D2 is related to olfaction, variations in olfactory receptor genes have been studied for potential links to olfactory disorders and other conditions. However, specific clinical implications of OR2D2 variations are not well-documented and require further research.

Research[edit]

Research into olfactory receptors like OR2D2 continues to expand our understanding of sensory perception and its genetic basis. Studies often focus on the diversity of olfactory receptors and their evolutionary significance.

References[edit]

External Links[edit]

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-'''OR2D2''' is a gene that encodes the olfactory receptor, family 2, subfamily D, member 2 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.
-== Function ==
+{{Infobox gene
+| name = OR2D2
+| symbol = OR2D2
+| HGNCid = 8181
+| chromosome = 6
+| arm = q
+| band = 23
+}}
-The protein encoded by the OR2D2 gene is an [[olfactory receptor]]. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.
+'''OR2D2''' is a gene that encodes a member of the olfactory receptor family of proteins. These proteins are involved in the detection of odor molecules and are part of the [[G protein-coupled receptor]] (GPCR) superfamily.
-== Gene ==
+==Function==
+Olfactory receptors, such as OR2D2, are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor proteins share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors, which allows them to interact with odorant molecules in the [[olfactory epithelium]] and initiate a neuronal response that triggers the perception of a smell.
-The OR2D2 gene is located on the [[chromosome 1]] (1q44). The gene spans approximately 1.1 kilobases and consists of 1 exon. The OR2D2 gene produces a mRNA molecule of approximately 1.1 kb in length.
+==Gene Family==
+The olfactory receptor gene family is the largest in the human genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. OR2D2 is part of the olfactory receptor family 2, subfamily D, member 2.
-== Clinical Significance ==
+==Location==
+The OR2D2 gene is located on the long arm (q) of [[chromosome 6]] at position 23. This location is significant for the study of genetic linkage and association with various traits and conditions.
-While the specific clinical significance of OR2D2 is not yet fully understood, olfactory receptors in general are thought to have roles in various human diseases such as [[cancer]], [[neurodegenerative diseases]], and [[genetic disorders]]. Further research is needed to elucidate the potential roles of OR2D2 in human health and disease.
+==Clinical Significance==
+While the primary function of OR2D2 is related to olfaction, variations in olfactory receptor genes have been studied for potential links to [[olfactory disorders]] and other conditions. However, specific clinical implications of OR2D2 variations are not well-documented and require further research.
-[[File:OR2D2 gene location on human chromosome 1.png|thumb|right|300px|Location of OR2D2 gene on human chromosome 1.]]
+==Research==
+Research into olfactory receptors like OR2D2 continues to expand our understanding of sensory perception and its genetic basis. Studies often focus on the diversity of olfactory receptors and their evolutionary significance.
-== See Also ==
+==See Also==
 * [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Chromosome 1]]
+* [[Chromosome 6]]
-== References ==
+==References==
-<references />
+{{Reflist}}
-[[Category:Genes on human chromosome 1]]
+==External Links==
+* [https://www.ncbi.nlm.nih.gov/gene/OR2D2 OR2D2 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2D2 OR2D2 Gene - GeneCards]
+[[Category:Genes on human chromosome 6]]
 [[Category:Olfactory receptors]]
 [[Category:G protein-coupled receptors]]
-{{G protein-coupled receptors}}
-{{Olfactory receptors}}
-{{medicine-stub}}