MTF1: Difference between revisions
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== | {{Infobox gene | ||
| name = MTF1 | |||
| caption = Metal regulatory transcription factor 1 | |||
| symbol = MTF1 | |||
| HGNCid = 7403 | |||
| OMIM = 600382 | |||
| EntrezGene = 4520 | |||
| RefSeq = NM_005955 | |||
| UniProt = Q14872 | |||
| chromosome = 1 | |||
| arm = p | |||
| band = 34 | |||
}} | |||
MTF1 is a [[ | '''MTF1''' (Metal Regulatory Transcription Factor 1) is a [[protein]] that in humans is encoded by the '''MTF1''' [[gene]]. This gene is located on [[chromosome 1]] at position p34. | ||
== | == Function == | ||
MTF1 is a [[transcription factor]] that binds to metal response elements (MREs) in the [[DNA]] sequence. It plays a crucial role in the regulation of [[metallothionein]] genes and other genes involved in [[metal homeostasis]]. MTF1 is activated in response to elevated levels of [[heavy metals]] such as [[zinc]], [[cadmium]], and [[copper]]. | |||
== Mechanism == | |||
Upon exposure to heavy metals, MTF1 translocates to the [[nucleus]] where it binds to MREs in the promoter regions of target genes. This binding initiates the transcription of genes that help in detoxifying and sequestering excess metals, thus protecting cells from [[metal toxicity]]. | |||
== Clinical Significance == | == Clinical Significance == | ||
Alterations in MTF1 function can lead to disorders related to metal metabolism. Overexpression or mutations in MTF1 may contribute to [[cancer]] progression by affecting [[cell proliferation]] and [[apoptosis]]. | |||
== Research == | |||
Studies have shown that MTF1 is involved in the cellular response to [[oxidative stress]] and [[hypoxia]]. It is also being investigated for its role in [[neurodegenerative diseases]] and [[cardiovascular diseases]]. | |||
[[ | |||
== See Also == | == See Also == | ||
* [[Transcription factor]] | * [[Transcription factor]] | ||
* [[ | * [[Metallothionein]] | ||
* [[Metal homeostasis]] | |||
== References == | == References == | ||
<references/> | |||
== External Links == | |||
* [https://www.ncbi.nlm.nih.gov/gene/4520 MTF1 Gene - NCBI] | |||
* [https://www.uniprot.org/uniprot/Q14872 MTF1 Protein - UniProt] | |||
{{ | {{Gene-1-stub}} | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
[[Category:Human proteins]] | [[Category:Human proteins]] | ||
[[Category:Genes | [[Category:Genes on human chromosome 1]] | ||
Latest revision as of 20:26, 30 December 2024
| Symbol | MTF1 |
|---|---|
| HGNC ID | 7403 |
| Alternative symbols | – |
| Entrez Gene | 4520 |
| OMIM | 600382 |
| RefSeq | NM_005955 |
| UniProt | Q14872 |
| Chromosome | 1p34 |
| Locus supplementary data | – |
MTF1 (Metal Regulatory Transcription Factor 1) is a protein that in humans is encoded by the MTF1 gene. This gene is located on chromosome 1 at position p34.
Function[edit]
MTF1 is a transcription factor that binds to metal response elements (MREs) in the DNA sequence. It plays a crucial role in the regulation of metallothionein genes and other genes involved in metal homeostasis. MTF1 is activated in response to elevated levels of heavy metals such as zinc, cadmium, and copper.
Mechanism[edit]
Upon exposure to heavy metals, MTF1 translocates to the nucleus where it binds to MREs in the promoter regions of target genes. This binding initiates the transcription of genes that help in detoxifying and sequestering excess metals, thus protecting cells from metal toxicity.
Clinical Significance[edit]
Alterations in MTF1 function can lead to disorders related to metal metabolism. Overexpression or mutations in MTF1 may contribute to cancer progression by affecting cell proliferation and apoptosis.
Research[edit]
Studies have shown that MTF1 is involved in the cellular response to oxidative stress and hypoxia. It is also being investigated for its role in neurodegenerative diseases and cardiovascular diseases.
See Also[edit]
References[edit]
<references/>
External Links[edit]
