SLC22A9: Difference between revisions
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'''SLC22A9''' is a gene that encodes a | {{Infobox gene | ||
| name = SLC22A9 | |||
| symbol = SLC22A9 | |||
| HGNCid = 10965 | |||
| chromosome = 11 | |||
| arm = q | |||
| band = 13.1 | |||
}} | |||
'''SLC22A9''' is a gene that encodes a member of the [[solute carrier family 22]] (SLC22), which is involved in the transport of organic ions across cell membranes. This family of transporters plays a crucial role in the [[pharmacokinetics]] of drugs and the [[excretion]] of endogenous compounds. | |||
== Function == | == Function == | ||
The SLC22A9 gene is responsible for | The SLC22A9 gene product is an organic anion transporter, which is primarily expressed in the [[liver]] and [[kidney]]. It is responsible for the uptake and excretion of a wide range of organic anions, including [[drugs]], [[metabolites]], and [[toxins]]. This transporter is important for the [[detoxification]] processes in the body and influences the [[bioavailability]] and [[clearance]] of various pharmacological agents. | ||
== Clinical Significance == | == Clinical Significance == | ||
Mutations in the SLC22A9 gene can | Mutations or variations in the SLC22A9 gene can affect drug response and toxicity. Understanding the function and regulation of this transporter can aid in the development of personalized medicine approaches, particularly in optimizing drug dosing and minimizing adverse drug reactions. Research into SLC22A9 may also provide insights into [[disease]] mechanisms where altered transport of organic anions is implicated. | ||
== Research == | == Research == | ||
Studies on SLC22A9 involve investigating its substrate specificity, regulatory mechanisms, and its role in [[drug-drug interactions]]. Researchers use various [[biochemical]] and [[molecular biology]] techniques to elucidate the structure-function relationship of this transporter. | |||
[[ | |||
== See Also == | == See Also == | ||
* [[Solute carrier family]] | * [[Solute carrier family]] | ||
* [[Organic anion transporter]] | * [[Organic anion transporter]] | ||
* [[ | * [[Pharmacogenomics]] | ||
== References == | == References == | ||
<references /> | <references/> | ||
== External Links == | |||
* [https://www.ncbi.nlm.nih.gov/gene/ SLC22A9 Gene - NCBI] | |||
* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC22A9 SLC22A9 Gene - GeneCards] | |||
{{Transporter-stub}} | |||
[[Category:Solute carrier family]] | |||
[[Category:Genes on human chromosome 11]] | |||
[[Category:Transport proteins]] | |||
[[Category:Pharmacogenomics]] | |||
Latest revision as of 20:22, 30 December 2024
| Symbol | SLC22A9 |
|---|---|
| HGNC ID | 10965 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 11q13.1 |
| Locus supplementary data | – |
SLC22A9 is a gene that encodes a member of the solute carrier family 22 (SLC22), which is involved in the transport of organic ions across cell membranes. This family of transporters plays a crucial role in the pharmacokinetics of drugs and the excretion of endogenous compounds.
Function[edit]
The SLC22A9 gene product is an organic anion transporter, which is primarily expressed in the liver and kidney. It is responsible for the uptake and excretion of a wide range of organic anions, including drugs, metabolites, and toxins. This transporter is important for the detoxification processes in the body and influences the bioavailability and clearance of various pharmacological agents.
Clinical Significance[edit]
Mutations or variations in the SLC22A9 gene can affect drug response and toxicity. Understanding the function and regulation of this transporter can aid in the development of personalized medicine approaches, particularly in optimizing drug dosing and minimizing adverse drug reactions. Research into SLC22A9 may also provide insights into disease mechanisms where altered transport of organic anions is implicated.
Research[edit]
Studies on SLC22A9 involve investigating its substrate specificity, regulatory mechanisms, and its role in drug-drug interactions. Researchers use various biochemical and molecular biology techniques to elucidate the structure-function relationship of this transporter.
See Also[edit]
References[edit]
<references/>
