OR1J2: Difference between revisions
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{{Infobox gene | |||
| name = OR1J2 | |||
| symbol = OR1J2 | |||
| HGNCid = 8191 | |||
| chromosome = 9 | |||
| arm = q | |||
| band = 34.3 | |||
| locus = 9q34.3 | |||
| gene_family = Olfactory receptors | |||
}} | |||
'''OR1J2''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are part of the [[G protein-coupled receptor]] (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of [[smell]]. | |||
== Function == | == Function == | ||
The OR1J2 gene is involved in the detection of odorants in the [[olfactory system]]. Olfactory receptors, including OR1J2, are expressed in the [[olfactory epithelium]] and are responsible for the recognition and G protein-mediated transduction of odorant signals. The OR1J2 protein is a [[transmembrane receptor]] that spans the cell membrane seven times, a characteristic feature of GPCRs. | |||
The protein | == Structure == | ||
The OR1J2 protein, like other olfactory receptors, has a 7-transmembrane domain structure. This structure is typical of many neurotransmitter and hormone receptors, which allows them to interact with G proteins and initiate a cellular response upon binding to an odorant molecule. | |||
== | == Genetic Information == | ||
The OR1J2 gene is located on [[chromosome 9]] at the q34.3 locus. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell. | |||
The OR1J2 gene is located on | |||
== Clinical Significance == | == Clinical Significance == | ||
While specific clinical implications of the OR1J2 gene are not well-documented, variations in olfactory receptor genes can affect an individual's sense of smell. Research into olfactory receptors like OR1J2 can provide insights into [[olfactory disorders]] and potential therapeutic targets for conditions affecting the sense of smell. | |||
While | |||
== See Also == | == See Also == | ||
* [[Olfactory receptor]] | * [[Olfactory receptor family]] | ||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[ | * [[Chromosome 9]] | ||
== References == | == References == | ||
{{Reflist}} | |||
[[ | == External Links == | ||
[[Category: | * [https://www.ncbi.nlm.nih.gov/gene/OR1J2 OR1J2 Gene - NCBI] | ||
* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR1J2 OR1J2 Gene - GeneCards] | |||
[[Category:Olfactory receptors]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category: | [[Category:Genes on human chromosome 9]] | ||
Latest revision as of 20:21, 30 December 2024
| Symbol | OR1J2 |
|---|---|
| HGNC ID | 8191 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 9q34.3 |
| Locus supplementary data | – |
OR1J2 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the G protein-coupled receptor (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of smell.
Function[edit]
The OR1J2 gene is involved in the detection of odorants in the olfactory system. Olfactory receptors, including OR1J2, are expressed in the olfactory epithelium and are responsible for the recognition and G protein-mediated transduction of odorant signals. The OR1J2 protein is a transmembrane receptor that spans the cell membrane seven times, a characteristic feature of GPCRs.
Structure[edit]
The OR1J2 protein, like other olfactory receptors, has a 7-transmembrane domain structure. This structure is typical of many neurotransmitter and hormone receptors, which allows them to interact with G proteins and initiate a cellular response upon binding to an odorant molecule.
Genetic Information[edit]
The OR1J2 gene is located on chromosome 9 at the q34.3 locus. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell.
Clinical Significance[edit]
While specific clinical implications of the OR1J2 gene are not well-documented, variations in olfactory receptor genes can affect an individual's sense of smell. Research into olfactory receptors like OR1J2 can provide insights into olfactory disorders and potential therapeutic targets for conditions affecting the sense of smell.
See Also[edit]
References[edit]
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