Melanocortin 3 receptor: Difference between revisions
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{{DISPLAYTITLE:Melanocortin 3 receptor}} | |||
{{Infobox protein | |||
| name = Melanocortin 3 receptor | |||
| image = <!-- Image removed --> | |||
| caption = <!-- Image caption --> | |||
| symbol = MC3R | |||
| HGNCid = 6931 | |||
| OMIM = 155541 | |||
| RefSeq = NM_019888 | |||
| UniProt = Q99705 | |||
| chromosome = 20 | |||
| arm = q | |||
| band = 13.2 | |||
}} | |||
The '''Melanocortin 3 receptor''' ('''MC3R''') is a [[G protein-coupled receptor]] that is encoded by the ''MC3R'' gene in humans. It is one of the five [[melanocortin receptors]] and is primarily expressed in the [[central nervous system]]. | |||
MC3R is a | |||
== Function == | == Function == | ||
MC3R is involved in the regulation of [[energy homeostasis]] and [[body weight]]. It is activated by [[melanocortin]] | The MC3R is involved in the regulation of [[energy homeostasis]], [[feeding behavior]], and [[body weight]]. It is activated by [[melanocortin peptides]], including [[alpha-MSH]] (alpha-melanocyte-stimulating hormone) and [[ACTH]] (adrenocorticotropic hormone). The receptor plays a role in the modulation of [[inflammatory responses]] and [[cardiovascular function]]. | ||
== Clinical | == Clinical Significance == | ||
Mutations in the MC3R gene have been associated with [[obesity]] and [[ | Mutations in the ''MC3R'' gene have been associated with [[obesity]] and [[metabolic disorders]]. Research suggests that the MC3R may influence [[insulin sensitivity]] and [[glucose metabolism]]. | ||
== See | == Ligands == | ||
* [[Melanocortin receptor]] | MC3R has several known ligands, including both agonists and antagonists. Agonists such as [[alpha-MSH]] and [[gamma-MSH]] activate the receptor, while antagonists can inhibit its activity. The development of selective MC3R ligands is of interest for potential therapeutic applications in treating obesity and metabolic diseases. | ||
== See Also == | |||
* [[Melanocortin 4 receptor]] | |||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[Energy homeostasis]] | * [[Energy homeostasis]] | ||
== References == | == References == | ||
<references /> | <references/> | ||
== External Links == | |||
* [https://www.ncbi.nlm.nih.gov/gene/4159 MC3R gene - NCBI] | |||
* [https://www.uniprot.org/uniprot/Q99705 MC3R protein - UniProt] | |||
{{Receptor-stub}} | |||
{{Protein-stub}} | |||
[[Category:Melanocortin receptors]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category:Human proteins]] | [[Category:Human proteins]] | ||
[[Category:Obesity]] | [[Category:Obesity]] | ||
[[Category: | [[Category:Metabolic disorders]] | ||
Latest revision as of 16:46, 29 December 2024
The Melanocortin 3 receptor (MC3R) is a G protein-coupled receptor that is encoded by the MC3R gene in humans. It is one of the five melanocortin receptors and is primarily expressed in the central nervous system.
Function[edit]
The MC3R is involved in the regulation of energy homeostasis, feeding behavior, and body weight. It is activated by melanocortin peptides, including alpha-MSH (alpha-melanocyte-stimulating hormone) and ACTH (adrenocorticotropic hormone). The receptor plays a role in the modulation of inflammatory responses and cardiovascular function.
Clinical Significance[edit]
Mutations in the MC3R gene have been associated with obesity and metabolic disorders. Research suggests that the MC3R may influence insulin sensitivity and glucose metabolism.
Ligands[edit]
MC3R has several known ligands, including both agonists and antagonists. Agonists such as alpha-MSH and gamma-MSH activate the receptor, while antagonists can inhibit its activity. The development of selective MC3R ligands is of interest for potential therapeutic applications in treating obesity and metabolic diseases.
See Also[edit]
References[edit]
<references/>
External Links[edit]
