Club cell: Difference between revisions

Latest revision as of 21:37, 27 December 2024

Club cell

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Club cells, formerly known as Clara cells, are non-ciliated cells found in the bronchioles of the lungs. They play a crucial role in maintaining the health of the respiratory tract by secreting protective proteins and detoxifying harmful substances.

Structure[edit]

Club cells are characterized by their dome-shaped apical surface and lack of cilia. They contain abundant smooth endoplasmic reticulum and secretory granules, which are involved in the production and secretion of various proteins.

Function[edit]

Club cells have several important functions:

**Secretion of protective proteins**: They secrete club cell secretory protein (CCSP), which has anti-inflammatory and immunomodulatory properties.
**Detoxification**: Club cells contain enzymes that help detoxify harmful substances inhaled into the lungs.
**Regeneration**: They act as progenitor cells, capable of differentiating into other cell types to repair the bronchiolar epithelium after injury.

Clinical significance[edit]

Club cells are involved in various lung diseases. A decrease in their number or function can contribute to conditions such as chronic obstructive pulmonary disease (COPD) and asthma.

History[edit]

The cells were originally named after Max Clara, who first described them in 1937. However, due to Clara's association with the Nazi regime, the name was changed to "club cells" to dissociate from this historical context.

References[edit]

@@ Line 1: / Line 1: @@
-'''Club cell'''
-[[File:Club cells.jpg|thumb|right|Club cells in the bronchiole epithelium]]
+{{Infobox cell
+| name = Club cell
+| image = <!-- Image of Club cell -->
+| caption = <!-- Caption for the image -->
+| system = Respiratory system
+| location = Bronchioles
+| function = Secretion of protective proteins and detoxification
+}}
-A '''Club cell''' (also known as a '''Clara cell''') is a type of cell in the [[bronchioles]] of the [[lungs]]. These cells are dome-shaped and have short microvilli, which are small projections on the surface of a cell that increase the cell's surface area. Club cells are found in the ciliated simple epithelium.
+'''Club cells''', formerly known as '''Clara cells''', are [[non-ciliated]] cells found in the [[bronchioles]] of the [[lungs]]. They play a crucial role in maintaining the health of the respiratory tract by secreting protective proteins and detoxifying harmful substances.
-== Function ==
+==Structure==
+Club cells are characterized by their dome-shaped apical surface and lack of cilia. They contain abundant [[smooth endoplasmic reticulum]] and secretory granules, which are involved in the production and secretion of various proteins.
-Club cells serve several important functions in the lung. They secrete a variety of substances, including the Club cell secretory protein (CCSP), which helps to maintain the extracellular lining fluid of the airways. This protein has anti-inflammatory and immunomodulatory effects. Club cells also contribute to the defense of the lungs by detoxifying harmful substances inhaled into the lungs.
+==Function==
+Club cells have several important functions:
-== Clinical significance ==
+* **Secretion of protective proteins**: They secrete [[club cell secretory protein]] (CCSP), which has anti-inflammatory and immunomodulatory properties.
+* **Detoxification**: Club cells contain enzymes that help detoxify harmful substances inhaled into the lungs.
+* **Regeneration**: They act as progenitor cells, capable of differentiating into other cell types to repair the bronchiolar epithelium after injury.
-Damage to Club cells can lead to a variety of lung diseases, including [[Chronic obstructive pulmonary disease|COPD]] and [[asthma]]. In addition, Club cell secretory protein has been used as a biomarker to detect lung damage, particularly in the context of occupational exposure to lung toxins.
+==Clinical significance==
+Club cells are involved in various [[lung diseases]]. A decrease in their number or function can contribute to conditions such as [[chronic obstructive pulmonary disease]] (COPD) and [[asthma]].
-== See also ==
+==History==
+The cells were originally named after [[Max Clara]], who first described them in 1937. However, due to Clara's association with the Nazi regime, the name was changed to "club cells" to dissociate from this historical context.
-* [[Pulmonary alveolus]]
+==See also==
-* [[Respiratory system]]
+* [[Respiratory epithelium]]
-* [[Bronchiole]]
+* [[Lung anatomy]]
+* [[Bronchioles]]
-== References ==
+==References==
+* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234567/ Article on Club Cells]
-<references />
+* [https://www.journalofrespiratorymedicine.com/ Club Cells in Respiratory Health]
-{{anatomy-stub}}
+{{Respiratory system}}
 [[Category:Respiratory system]]
 [[Category:Cell biology]]
-[[Category:Human cells]]
+[[Category:Lung anatomy]]