IGKC

Ideogram human chromosome 2

Immunoglobulin kappa constant (IGKC) is a gene located on chromosome 2 in humans that encodes the constant region of the kappa light chain of immunoglobulins. This gene is essential for the production of immunoglobulins, which are antibodies that play a crucial role in the immune system's defense against pathogens.

Structure

The IGKC gene consists of multiple exons that encode the constant region of the kappa light chain. This region is responsible for the effector functions of the antibody molecule, such as binding to antigens and activating immune responses.

Function

The primary function of IGKC is to provide the structural framework for the kappa light chain of immunoglobulins. When B cells are activated during an immune response, they undergo a process called class switching, where they switch the constant region of their antibody molecules from IgM to IgG, IgA, or IgE. IGKC is involved in this process by maintaining the constant region of the kappa light chain.

Clinical Significance

Mutations or dysregulation of the IGKC gene can lead to immunodeficiency disorders or autoimmune diseases. Defects in IGKC expression or function can impair the production of functional antibodies, compromising the body's ability to fight infections.

See Also

• Immunoglobulin
• Antibody
• B cell
• Chromosome 2

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